POLR2E

DNA-directed RNA polymerases I, II, and III subunit RPABC1 · P19388 · POLR2E on Sugi Atlas →

0 patent compounds predicted against POLR2E, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to POLR2E by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A RCT of TNF and ENT in the Treatment of Long-term Prognosis With Hepatitis B-related HCC After Curative Resection PHASE3UNKNOWN
Intracameral Antibiotic Safety Study PHASE3SUSPENDED
Investigating Datopotamab Deruxtecan Plus Durvalumab Versus Datopotamab Deruxtecan in Patients With PDL1-negative Metastatic Triple-negative Breast Cancer PHASE2RECRUITING
Clinical Study of EBV-LMP1 Targeted DNAzyme to Treat Nasopharyngeal Carcinoma PHASE1/PHASE2COMPLETED
Trial of Topotecan With VX-970 (M6620), an ATR Kinase Inhibitor, in Small Cell Cancers and Extrapulmonary Small Cell Cancers PHASE1/PHASE2COMPLETED
Intraarterial Carboplatin + Caelyx vs Intraarterial Carboplatin + Etoposide Phosphate for Progressing Glioblastoma PHASE2RECRUITING
Durvalumab for MSI-H or POLE Mutated Metastatic Colorectal Cancer PHASE2COMPLETED
Danazol for Treatment of Cytopenias in Patients With Cirrhosis PHASE2RECRUITING
Genomic and Transcriptomic Predictors of Sequential SG Sensitivity After T-DXd in ER+/HER2-Low Metastatic Breast Cancer PHASE2RECRUITING
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome PHASE1COMPLETED
A Study of ART4215 for the Treatment of Advanced or Metastatic Solid Tumors PHASE1COMPLETED
Spironolactone and XPB-1 Integrity in the TFIIH Complex nanENROLLING_BY_INVITATION
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors nanCOMPLETED
Effect of Adenovirus E1A Oncogene on DNA Replication Dynamics nanUNKNOWN
DNA Damage & Repair Proteins In Patients With Atherosclerotic Coronary Artery Disease nanCOMPLETED
Recombinant Interferon Alfa-2b in Treating Patients With Melanoma nanCOMPLETED
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients nanCOMPLETED
Chromosomal Translocations in Chandigarh Police nanCOMPLETED
Cohort of Tumors With POLE/D1 Mutation nanRECRUITING
Choroid Plexus Dysfunction in Neurological Diseases nanRECRUITING
S8814A Biomarkers in Predicting Outcome in Postmenopausal Women With Hormone Receptor-Positive, Node-Positive Breast Cancer Treated With Tamoxifen With or Without Cyclophosphamide, Doxorubicin, and Fluorouracil nanCOMPLETED
Clinical Manifestations and Biomarkers in Amyotrophic Lateral Sclerosis Type 4 and Other Inherited Neurological Disorders of RNA Processing nanRECRUITING
S9031-S9126-S9333-S9500-B Biomarker Expression in Patients With Acute Myeloid Leukemia nanCOMPLETED
Genetic Investigation of Cancer Predisposition nanNOT_YET_RECRUITING
Study of Specimens From Young Patients With Neuroblastoma nanCOMPLETED
miR-155 Expression in Episodic and Chronic Migraine nanUNKNOWN
A Comparison of p53-induced Genes Activation in Patients With and Without Acute Myocardial Infarction nanCOMPLETED
Chronic Cough and CANVAS (Cerebellar Ataxia With Neuropathy and Bilateral Vestibular Areflexia Syndrome) nanCOMPLETED
A Study of Biological, Genetic, and Constitutional Factors and Non-invasive Monitoring to Assess Personal Cancer Risks nanRECRUITING
Plant Extracted Natural Compounds Impact on Stage IV Breast Cancer Survival Time and Remission. nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a POLR2E binder may also engage these)

ProteinNameSimilarity
Q2T9T3 1.000 Q2T9T3 →
Q80UW8 1.000 Q80UW8 →
B0BNE2 1.000 B0BNE2 →
A8XGH1 1.000 A8XGH1 →
Q5R587 1.000 Q5R587 →
Q9N5K2 0.997 Q9N5K2 →
Q6BIJ0 0.994 Q6BIJ0 →
Q09191 0.994 Q09191 →
Q54EH2 0.992 Q54EH2 →
Q757H7 0.992 Q757H7 →
P20434 0.990 P20434 →
Q9P4B9 0.990 Q9P4B9 →
Q6FQA6 0.988 Q6FQA6 →
Q6CA26 0.987 Q6CA26 →
Q6CJ62 0.986 Q6CJ62 →
Q9FJL8 0.984 Q9FJL8 →
Q9VD25 0.981 Q9VD25 →
P50444 0.979 P50444 →
P09445 0.978 P09445 →
Q17029 0.978 Q17029 →
EEF2 Elongation factor 2 0.977 landscape →
Q8CGK3 0.977 Q8CGK3 →
Q5R8Z3 0.976 Q5R8Z3 →
Q9W3C1 0.976 Q9W3C1 →
A1DH48 0.976 A1DH48 →
B6K286 0.976 B6K286 →
P05197 0.976 P05197 →
P55823 0.976 P55823 →
P31478 0.976 P31478 →
O43046 0.976 O43046 →