⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14775507 | 0.81 | — | — | |
| SCHEMBL14997322 | 0.79 | — | — | |
| SCHEMBL7866106 | 0.79 | ALDH1A1 (0.40) | — | |
| SCHEMBL8491751 | 0.79 | TSHR (0.48) | — | |
| SCHEMBL9323497 | 0.79 | TSHR (0.46) | — | |
| SCHEMBL80308 | 0.78 | — | — | |
| SCHEMBL5792192 | 0.77 | TSHR (0.46) | — | |
| SCHEMBL5703488 | 0.77 | TSHR (0.46) | — | |
| SCHEMBL16316794 | 0.77 | — | — | |
| SCHEMBL359717 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11174273-B2 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2021-11-16 | — | — | US | disclosed |
| US-20210284656-A9 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2021-09-16 | — | — | US | disclosed |
| US-20190161500-A1 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2019-05-30 | — | — | US | disclosed |
| US-10221194-B2 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2019-03-05 | — | — | US | disclosed |
| US-20170260202-A1 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2017-09-14 | — | — | US | disclosed |
| US-9676791-B2 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2017-06-13 | — | — | US | disclosed |
| CN-103772373-B | As the quinazoline analogs of receptor tyrosine kinase inhibitors | 阿雷生物药品公司 | 2017-06-09 | — | — | CN | disclosed |
| US-9527865-B2 | — | — | 2016-12-27 | — | — | US | disclosed |
| CN-102432552-B | As the quinazoline analogs of receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-01-20 | — | — | CN | disclosed |
| CN-102803185-B | Fuel composition comprising isoprene derivative | DANISCO US INC. (US) | 2016-01-06 | — | — | CN | disclosed |
| US-20110046422-A1 | FUEL COMPOSITIONS COMPRISING ISOPRENE DERIVATIVES | DANISCO US INC. | 2011-02-24 | — | — | US | disclosed |
| WO-2010148256-A1 | FUEL COMPOSITIONS COMPRISING ISOPRENE DERIVATIVES | DANISCO US INC. (US) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010148256-A1 | FUEL COMPOSITIONS COMPRISING ISOPRENE DERIVATIVES | DANISCO US INC. (US) | 2010-12-23 | — | — | WO | disclosed |
| US-20090048279-A1 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-02-19 | — | — | US | disclosed |
| EP-1660090-A4 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2008-12-03 | — | — | EP | disclosed |
| US-7452895-B2 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2008-11-18 | — | — | US | disclosed |
| EP-1660090-A1 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2006-05-31 | — | — | EP | disclosed |
| US-20050043334-A1 | Quinazoline analogs as receptor tyrosine kinase inhibitors | ARRAY BIOPHARMA INC. | 2005-02-24 | — | — | US | disclosed |
| WO-2005016346-A1 | QUINAZOLINE ANALOGS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2005-02-24 | — | — | WO | disclosed |
| US-3996303-A | Organic halide | KURARAY CO., LTD. (JA) | 1976-12-07 | — | — | US | disclosed |