Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLA1 | P09884 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280136 | 1.00 | SOD1 (0.40) | SOD1MEN1KMT2APOLBHSP90AA1 | |
| SCHEMBL279974 | 1.00 | SOD1 (0.40) | SOD1MEN1KMT2APOLBHSP90AA1 | |
| SCHEMBL12872356 | 1.00 | SOD1 (0.40) | SOD1MEN1KMT2APOLBHSP90AA1 | |
| SCHEMBL280322 | 1.00 | SOD1 (0.40) | SOD1MEN1KMT2APOLBHSP90AA1 | |
| SCHEMBL267258 | 0.76 | CYP3A4 (0.36) | MEN1KMT2ACYP3A4MAPTMAPK1 | |
| SCHEMBL280131 | 0.76 | HSP90AA1 (0.41) | SOD1MEN1KMT2APOLBHSP90AA1 | |
| SCHEMBL12522489 | 0.76 | HSP90AA1 (0.41) | SOD1MEN1KMT2APOLBHSP90AA1 | |
| SCHEMBL6009568 | 0.76 | HSP90AA1 (0.41) | SOD1MEN1KMT2APOLBHSP90AA1 | |
| SCHEMBL280269 | 0.74 | MEN1 (0.40) | SOD1MEN1KMT2APOLBHSP90AA1 | |
| SCHEMBL14401278 | 0.74 | MEN1 (0.43) | SOD1MEN1KMT2APOLBHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311795-A2 | Interleukin-1 and tumor necrosis factor-alpha modulators; syntheses of such modulators and methods of using such modulators | Nereus Pharmaceuticals, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |