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SOD1

Superoxide dismutase [Cu-Zn] · P00441 · SOD1 on Sugi Atlas →

4,011 patent compounds predicted against SOD1, 2,553 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2439299 SCHEMBL2439299 1.00 15/20
SCHEMBL2440324 SCHEMBL2440324 0.53 11/20
SCHEMBL688485 SCHEMBL688485 0.40 9/20
SCHEMBL2443235 SCHEMBL2443235 1.00 6/20
SCHEMBL3475457 SCHEMBL3475457 0.35 4/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL3872082) 0.60 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL1844874) 0.58 3/20
SCHEMBL4085125 SCHEMBL4085125 0.58 3/20
SCHEMBL2539814 SCHEMBL2539814 0.57 3/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL5191266) 0.56 3/20
SCHEMBL3978895 SCHEMBL3978895 0.54 3/20
SCHEMBL4138098 SCHEMBL4138098 0.54 3/20
SCHEMBL5903394 SCHEMBL5903394 0.54 3/20
SCHEMBL6092843 SCHEMBL6092843 0.54 3/20
SCHEMBL3538008 SCHEMBL3538008 0.54 3/20
SCHEMBL3538009 SCHEMBL3538009 0.54 3/20
SCHEMBL1841246 SCHEMBL1841246 0.54 3/20
SCHEMBL5551707 SCHEMBL5551707 0.53 3/20
SCHEMBL1089224 SCHEMBL1089224 0.53 3/20
SCHEMBL3976448 SCHEMBL3976448 0.53 3/20

Clinical trials — most relevant to SOD1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese Participants With SOD-1 Amyotrophic Lateral Sclerosis (ALS) PHASE4RECRUITING
Adding Dexmedetomidine to Bupivacaine for Bilateral Erector Spinae Block PHASE4UNKNOWN
Long-Term Evaluation of BIIB067 (Tofersen) PHASE3COMPLETED
Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy PHASE3RECRUITING
A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismutase 1 Mutation PHASE3ACTIVE_NOT_RECRUITING
Randomized Controlled Trial of Silymarin in Asthma PHASE2/PHASE3WITHDRAWN
SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS) PHASE1/PHASE2COMPLETED
Safety Study of High Doses of Zinc in ALS Patients PHASE1/PHASE2COMPLETED
First in Human (FIH) Study of ALN-SOD in Adult Participants With Amyotrophic Lateral Sclerosis Associated With Mutation in the SOD1 Gene (SOD1-ALS) PHASE1/PHASE2RECRUITING
Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy PHASE2RECRUITING
Mexiletine in Sporadic Amyotrophic Lateral Sclerosis (SALS) PHASE2COMPLETED
Mexiletine in Sporadic Amyotrophic Lateral Sclerosis PHASE2COMPLETED
Beneficial Effect of Silymarin in Ulcerative Colitis PHASE2RECRUITING
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RAG-17 in Subjects With Amyotrophic Lateral Sclerosis (ALS) With Superoxide Dismutase Type 1 (SOD1) Gene Mutation PHASE1RECRUITING
Safety, Tolerability, and Activity Study of ISIS SOD1Rx to Treat Familial Amyotrophic Lateral Sclerosis (ALS) Caused by SOD1 Gene Mutations PHASE1COMPLETED
[18F]ACI-19626 PET in TDP-43 Proteinopathies EARLY_PHASE1RECRUITING
A Study to Evaluate the Tolerability, Safety and Efficacy of VGN-R13 in Patients with ALS EARLY_PHASE1RECRUITING
Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis nanCOMPLETED
SOD1 Kinetics Measurements in ALS Patients nanSUSPENDED
Efficacy and Safety of Ovotransferrin in COVID-19 Patients nanUNKNOWN
The Influence of Melatonin Supplementation in the Group of Persons Performing Competitive Sport. nanCOMPLETED
A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismutase 1 (SOD-1) Amyotrophic Lateral Sclerosis (ALS) nanRECRUITING
ADAPT: Efficacy of a Dietary Supplement During and After Exercise nanCOMPLETED
Genomic Translation for Amyotrophic Lateral Sclerosis Care nanCOMPLETED
Efficacy of Superoxide Dismutase in Preventing Radiation Dermatitis in Patients With Head and Neck Cancer . nanWITHDRAWN
Treatment of Refractory Schizophrenia With Riluzole nanCOMPLETED
Pleiotropy and Mechanism of Peripheral Nerve Related Genes in the Progression of Amyotrophic Lateral Sclerosis nanUNKNOWN
Effects of Green Tea Extract (GTE) on Systemic Oxidative and Antioxidative Status in Chinese Patients With Stable Asthma nanCOMPLETED
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome nanCOMPLETED
Efficacy of Superoxide Dismutase Spray in Preventing Radiation Dermatitis in Patients With Head and Neck Cancer . nanWITHDRAWN

Related proteins — ESM-2 sequence neighbours (a SOD1 binder may also engage these)

ProteinNameSimilarity
P60052 — 1.000 P60052 →
Q8HXP9 — 1.000 Q8HXP9 →
Q8HXQ1 — 1.000 Q8HXQ1 →
Q8HXQ2 — 1.000 Q8HXQ2 →
H6BDU4 — 1.000 H6BDU4 →
Q8HXQ0 — 1.000 Q8HXQ0 →
Q8HXQ3 — 1.000 Q8HXQ3 →
P80566 — 1.000 P80566 →
Q8HXP8 — 1.000 Q8HXP8 →
Q55GQ5 — 1.000 Q55GQ5 →
P13926 — 1.000 P13926 →
P07632 — 1.000 P07632 →
O46412 — 1.000 O46412 →
Q0IIW3 — 1.000 Q0IIW3 →
Q52RN5 — 1.000 Q52RN5 →
Q8WNN6 — 1.000 Q8WNN6 →
P08228 — 0.999 P08228 →
Q9U4X5 — 0.999 Q9U4X5 →
Q8HXQ4 — 0.999 Q8HXQ4 →
P00442 — 0.999 P00442 →
P09670 — 0.999 P09670 →
P00443 — 0.998 P00443 →
Q5FB29 — 0.997 Q5FB29 →
O65768 — 0.997 O65768 →
Q9C0N4 — 0.997 Q9C0N4 →
O73872 — 0.997 O73872 →
P81926 — 0.997 P81926 →
P24706 — 0.996 P24706 →
P85978 — 0.996 P85978 →
Q07182 — 0.996 Q07182 →