Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12706234 | 0.91 | PPARG (0.45) | PPARGPPARAATMALDH1A1ACE | |
| SCHEMBL2549195 | 0.89 | PPARG (0.47) | PPARGPPARAATMACECTSS | |
| SCHEMBL2549196 | 0.89 | PPARG (0.47) | PPARGPPARAATMACECTSS | |
| SCHEMBL1519701 | 0.87 | ATM (0.51) | PPARGPPARAATMACECTSS | |
| SCHEMBL13286104 | 0.87 | PPARG (0.46) | PPARGPPARAATMACECTSS | |
| SCHEMBL12765909 | 0.86 | PPARG (0.50) | PPARGPPARAATMCTSSCTSK | |
| SCHEMBL13970938 | 0.86 | PPARG (0.49) | PPARGPPARAATMACECTSS | |
| SCHEMBL20415728 | 0.85 | ATM (0.46) | PPARGPPARAATMALDH1A1ACE | |
| SCHEMBL4659427 | 0.85 | ATM (0.50) | PPARGPPARAATMACECTSS | |
| SCHEMBL14430204 | 0.85 | ATM (0.50) | PPARGPPARAATMACECTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919504-B2 | Thiadiazole modulators of PKB | AMGEN INC. (US) | 2011-04-05 | — | — | US | disclosed |
| US-20090298836-A1 | Thiadiazole modulators of PKB | AMGEN INC. (US) | 2009-12-03 | — | — | US | disclosed |
| WO-2009011871-A2 | THIADIAZOLE MODULATORS OF PKB | AMGEN INC. (US) | 2009-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298836-A1 | Thiadiazole modulators of PKB | PDK1, PDK2, MTOR | PPARG 361/4885PPARA 781/4885ATM 317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.