Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mk-2461. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET known ✓ | P08581 | 20/20 | 0.98 |
| ▸ | MST1R | Q04912 | 2/20 | 0.98 |
| ▸ | AURKA | O14965 | 1/20 | 0.98 |
| ▸ | JAK2 | O60674 | 1/20 | 0.98 |
| ▸ | ABL1 | P00519 | 1/20 | 0.98 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.98 |
| ▸ | RET | P07949 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.98 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | NQO2 | P16083 | 1/20 | 0.98 |
| ▸ | FLT1 | P17948 | 1/20 | 0.98 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.98 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.98 |
| ▸ | FECH | P22830 | 1/20 | 0.98 |
| ▸ | FLT4 | P35916 | 1/20 | 0.98 |
| ▸ | KDR | P35968 | 1/20 | 0.98 |
| ▸ | FLT3 | P36888 | 1/20 | 0.98 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mk-2461 SCHEMBL29356324 | 0.99 | MET (1.00) | METMST1RAURKAJAK2ABL1 | |
| Mk-2461 SCHEMBL29529144 | 0.99 | MET (1.00) | METMST1RAURKAJAK2ABL1 | |
| Mk-2461 SCHEMBL29394185 | 0.99 | MET (1.00) | METMST1RAURKAJAK2ABL1 | |
| Mk-2461 SCHEMBL93526 | 0.99 | MET (1.00) | METMST1RAURKAJAK2ABL1 | |
| Mk-2461 SCHEMBL2326614 | 0.99 | MET (1.00) | METMST1RAURKAJAK2ABL1 | |
| Mk-2461 SCHEMBL2326906 | 0.99 | MET (1.00) | METMST1RAURKAJAK2ABL1 | |
| Mk-2461 SCHEMBL1270766 | 0.98 | MET (0.98) | METMST1RAURKAJAK2ABL1 | |
| Mk-2461 SCHEMBL1269865 | 0.98 | MET (0.98) | METMST1RAURKAJAK2ABL1 | |
| Mk-2461 SCHEMBL1269863 | 0.98 | MET (0.98) | METMST1RAURKAJAK2ABL1 | |
| SCHEMBL4316174 | 0.91 | MET (0.84) | METMST1RAURKAJAK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7893081-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2011-02-22 | — | — | US | claimed |
| US-20090182002-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME LLC | 2009-07-16 | — | — | US | claimed |
| US-7893081-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2011-02-22 | — | — | US | disclosed |
| US-20090182002-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME LLC | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090182002-A1 | Tyrosine kinase inhibitors | JAK1, JAK2, LCK | MET 19/4885MST1R 41/4885AURKA 1020/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.