SCHEMBL12709502

SCHEMBL12709502

CCN1CCN(CI)C(=O)C1=O

nearest known ligand 0.42

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
POLB P06746 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.34
ALOX15 P16050 1/20 0.33
HTT P42858 1/20 0.32
F2 P00734 1/20 0.31
ELANE P08246 1/20 0.31
CTSG P08311 1/20 0.31
CTRC Q99895 1/20 0.31
INMT O95050 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12566554 0.87 GAA (0.48) GAAL3MBTL1POLBSMN1; SMN2ALOX15
SCHEMBL10751018 0.81 F2 (0.36) GAAL3MBTL1SMN1; SMN2ALOX15HTT
SCHEMBL12208453 0.76 GAA (0.42) GAAL3MBTL1POLBSMN1; SMN2ALOX15
SCHEMBL10967106 0.76 GAA (0.42) GAAL3MBTL1POLBSMN1; SMN2ALOX15
SCHEMBL7148826 0.76 GAA (0.46) GAAL3MBTL1POLBSMN1; SMN2ALOX15
SCHEMBL7139392 0.76 GAA (0.42) GAAL3MBTL1POLBSMN1; SMN2ALOX15
SCHEMBL7145277 0.76 GAA (0.42) GAAL3MBTL1POLBSMN1; SMN2ALOX15
SCHEMBL28533846 0.74 GAA (0.41) GAAL3MBTL1POLBSMN1; SMN2ALOX15
SCHEMBL10964562 0.73 GAA (0.40) GAAL3MBTL1POLBSMN1; SMN2ALOX15
SCHEMBL12545892 0.73 PIK3CD (0.48) GAAL3MBTL1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011045702-A1 PYRROLO[2,3-D] PYRIMIDINE COMPOUNDS PFIZER INC. (US) 2011-04-21 WO disclosed