Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 19/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12711413 | 0.93 | BDKRB2 (0.43) | BDKRB2 | |
| SCHEMBL12711434 | 0.85 | BDKRB2 (0.49) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL12711425 | 0.85 | BDKRB2 (0.51) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL12711804 | 0.83 | BDKRB2 (0.57) | BDKRB2 | |
| SCHEMBL12711889 | 0.80 | BDKRB2 (0.63) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL12711476 | 0.80 | BDKRB2 (0.64) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL12711912 | 0.79 | BDKRB2 (0.59) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL12711890 | 0.78 | BDKRB2 (0.41) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL13093145 | 0.78 | BDKRB2 (0.46) | BDKRB2CYP3A4CYP2C19 | |
| SCHEMBL12711411 | 0.78 | BDKRB2 (0.43) | BDKRB2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305668-A1 | 8-oxy-quinoline derivatives as bradykinin B2 receptor modulators | Jerini AG (DE) | 2011-04-06 | — | — | EP | disclosed |
| EP-2144897-B1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2010-10-20 | — | — | EP | disclosed |
| WO-2008116620-A1 | 8-OXY-QUINOLINE DERIVATIVES AS BRADYKININ B2 RECEPTOR MODULATORS | JERINI AG (DE) | 2008-10-02 | — | — | WO | disclosed |