Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | KIT | P10721 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15314506 | 0.93 | BTK (0.66) | BTKLCKLYNFLT3 | |
| SCHEMBL15314505 | 0.90 | BTK (0.67) | BTKLCKLYNKITFLT3 | |
| SCHEMBL13308556 | 0.88 | BTK (0.76) | BTKLCKKITFLT3 | |
| SCHEMBL13337309 | 0.86 | BTK (0.84) | BTKLCKLYNKITFLT3 | |
| SCHEMBL12712643 | 0.86 | BTK (0.63) | BTKLCKLYNKITFLT3 | |
| SCHEMBL3361369 | 0.80 | BTK (0.78) | BTKKITFLT3 | |
| SCHEMBL3361363 | 0.80 | BTK (0.78) | BTKKITFLT3 | |
| SCHEMBL3366857 | 0.80 | BTK (0.91) | BTKLCKKITFLT3 | |
| SCHEMBL17951514 | 0.80 | BTK (0.81) | BTKLCKLYNKITFLT3 | |
| SCHEMBL19649312 | 0.80 | BTK (0.81) | BTKLCKLYNKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9012463-B2 | Inhibitors of bruton's tyrosine kinase | PHARMACYCLICS, INC. (US) | 2015-04-21 | — | — | US | disclosed |
| US-20110086866-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | PHARMACYCLICS, INC. (US) | 2011-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110086866-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | ABL1, BTK, ABL2 | BTK 2/4885LCK 19/4885LYN 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.