Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | ELANE | P08246 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | C1R | P00736 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1589854 | 0.92 | NPC1 (0.72) | NPC1RAB9AELANEKMT2AMEN1 | |
| SCHEMBL1589852 | 0.92 | NPC1 (0.72) | NPC1RAB9AELANEKMT2AMEN1 | |
| SCHEMBL134146 | 0.88 | NPC1 (0.67) | NPC1RAB9AELANEKMT2AMEN1 | |
| SCHEMBL12723508 | 0.88 | ELANE (0.70) | NPC1RAB9AELANEKMT2AMEN1 | |
| SCHEMBL12723511 | 0.87 | NPC1 (0.74) | NPC1RAB9AELANEKMT2AMEN1 | |
| SCHEMBL1589944 | 0.85 | NPC1 (0.71) | NPC1RAB9AELANEKMT2AMEN1 | |
| SCHEMBL1590369 | 0.85 | NPC1 (0.71) | NPC1RAB9AELANEKMT2AMEN1 | |
| SCHEMBL1590366 | 0.85 | NPC1 (0.71) | NPC1RAB9AELANEKMT2AMEN1 | |
| SCHEMBL1589946 | 0.85 | NPC1 (0.71) | NPC1RAB9AELANEKMT2AMEN1 | |
| SCHEMBL12723706 | 0.83 | NPC1 (0.48) | NPC1RAB9AELANEKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011047432-A1 | FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2011-04-28 | — | — | WO | disclosed |