Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | ELANE | P08246 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 9/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1589854 | 0.90 | NPC1 (0.72) | NPC1RAB9AELANEMEN1KMT2A | |
| SCHEMBL1589852 | 0.90 | NPC1 (0.72) | NPC1RAB9AELANEMEN1KMT2A | |
| SCHEMBL12723717 | 0.88 | NPC1 (0.70) | NPC1RAB9AELANEMEN1KMT2A | |
| SCHEMBL19695932 | 0.86 | ELANE (0.57) | NPC1RAB9AELANEMEN1KMT2A | |
| SCHEMBL1589946 | 0.86 | NPC1 (0.71) | NPC1RAB9AELANEMEN1KMT2A | |
| SCHEMBL1590366 | 0.86 | NPC1 (0.71) | NPC1RAB9AELANEMEN1KMT2A | |
| SCHEMBL1589944 | 0.86 | NPC1 (0.71) | NPC1RAB9AELANEMEN1KMT2A | |
| SCHEMBL1590369 | 0.86 | NPC1 (0.71) | NPC1RAB9AELANEMEN1KMT2A | |
| SCHEMBL13556324 | 0.85 | ELANE (0.65) | NPC1RAB9AELANEMEN1KMT2A | |
| SCHEMBL19695931 | 0.84 | APP (0.49) | NPC1RAB9AMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9839640-B2 | Methods of treating eye diseases associated with inflammation and vascular proliferation | OCCURX PTY LTD (AU) | 2017-12-12 | — | — | US | disclosed |
| US-9062076-B2 | Fused ring analogues of anti-fibrotic agents | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2015-06-23 | — | — | US | disclosed |
| US-8420850-B2 | Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers | Iberhospitex, S.A (ES) | 2013-04-16 | — | — | US | disclosed |
| US-8420850-B2 | Compounds for the synthesis of biostable polyurethane, polyurea or polyurea urethane polymers | Iberhospitex, S.A (ES) | 2013-04-16 | — | — | US | disclosed |
| US-20120270863-A1 | FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2012-10-25 | — | — | US | disclosed |
| US-20120059117-A1 | COMPOUNDS FOR THE SYNTHESIS OF BIOSTABLE POLYURETHANE, POLYUREA OR POLYUREA URETHANE POLYMERS | IBERHOSPITEX, S.A. | 2012-03-08 | — | — | US | disclosed |
| US-20120059117-A1 | COMPOUNDS FOR THE SYNTHESIS OF BIOSTABLE POLYURETHANE, POLYUREA OR POLYUREA URETHANE POLYMERS | IBERHOSPITEX, S.A. | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270863-A1 | FUSED RING ANALOGUES OF ANTI-FIBROTIC AGENTS | MMP1, FIBP, COL2A1 | NPC1 1936/4885RAB9A 2239/4885ELANE 35/4885 |
| US-20120059117-A1 | COMPOUNDS FOR THE SYNTHESIS OF BIOSTABLE POLYURETHANE, POLYUREA OR POLYUREA URETHANE POLYMERS | PUF60, UMPS, UGP2 | NPC1 4694/4885RAB9A 4356/4885ELANE 2434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.