Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.53 |
| ▸ | CA2 | P00918 | 7/20 | 0.53 |
| ▸ | CA9 | Q16790 | 7/20 | 0.53 |
| ▸ | CA12 | O43570 | 4/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.48 |
| ▸ | STK16 | O75716 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.48 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 3/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634271 | 0.84 | MAPK10 (0.48) | CA1CA2CA9CA12TBK1 | |
| SCHEMBL1632397 | 0.83 | TBK1 (0.57) | CA1CA2CA9CA12TBK1 | |
| SCHEMBL3999932 | 0.78 | CA12 (0.62) | CA1CA2CA9CA12CA7 | |
| SCHEMBL1634316 | 0.78 | TBK1 (0.57) | CA1CA2CA9CA12TBK1 | |
| SCHEMBL1633121 | 0.78 | MAPK10 (0.52) | CA1CA2CA9CA12TBK1 | |
| SCHEMBL1633872 | 0.76 | CDK2 (0.52) | CA1CA2CA9CA12CA7 | |
| SCHEMBL1634662 | 0.76 | MAPK10 (0.56) | CA1CA2CA9CA12TBK1 | |
| SCHEMBL1634505 | 0.76 | TBK1 (0.55) | CA1CA2CA9CA12TBK1 | |
| SCHEMBL1633530 | 0.76 | JAK2 (0.58) | TYK2JAK2JAK3CDK1 | |
| SCHEMBL1632811 | 0.75 | JAK2 (0.54) | CA1CA2CA9TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |