Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12792428 | 0.88 | ADRB3 (0.40) | SMN1; SMN2POLBADRB3ADRA2BADRA2C | |
| SCHEMBL6760115 | 0.87 | POLB (0.37) | SMN1; SMN2POLBADRB3ADRA2BADRA2C | |
| SCHEMBL2843889 | 0.87 | POLB (0.37) | SMN1; SMN2POLBADRB3ADRA2BADRA2C | |
| SCHEMBL2610949 | 0.87 | SMN1; SMN2 (0.38) | SMN1; SMN2POLBALDH1A1MAPTCCNA2 | |
| SCHEMBL8238400 | 0.87 | POLB (0.37) | SMN1; SMN2POLBADRB3ADRA2BADRA2C | |
| SCHEMBL2843887 | 0.87 | POLB (0.37) | SMN1; SMN2POLBADRB3ADRA2BADRA2C | |
| SCHEMBL2131139 | 0.87 | ALDH1A1 (0.36) | SMN1; SMN2POLBADRB3ADRA2BADRA2C | |
| SCHEMBL2131141 | 0.87 | ALDH1A1 (0.36) | SMN1; SMN2POLBADRB3ADRA2BADRA2C | |
| SCHEMBL14020643 | 0.86 | POLB (0.38) | SMN1; SMN2POLBADRB3ADRA2BADRA2C | |
| SCHEMBL2135272 | 0.86 | ADRB3 (0.39) | SMN1; SMN2POLBADRB3ADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110081315-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2011-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110081315-A1 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, EIF4A2 | SMN1; SMN2 3157/4885POLB 523/4885ADRB3 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.