Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | BMP1 | P13497 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1602148 | 0.99 | SPPL2A (0.47) | SPPL2AALDH1A1MEP1BTAS2R14HPGD | |
| SCHEMBL1602077 | 0.92 | SPPL2A (0.47) | SPPL2AALDH1A1HPGDHTTLMNA | |
| SCHEMBL4347242 | 0.89 | SPPL2A (0.41) | SPPL2AALDH1A1MEP1BTAS2R14LMNA | |
| SCHEMBL4165957 | 0.88 | SPPL2A (0.41) | SPPL2AALDH1A1MEP1BTAS2R14LMNA | |
| SCHEMBL13950812 | 0.86 | SPPL2A (0.44) | SPPL2AALDH1A1LMNAPSEN1PSEN2 | |
| SCHEMBL1602297 | 0.86 | SPPL2A (0.44) | SPPL2AALDH1A1LMNAPSEN1PSEN2 | |
| SCHEMBL1600562 | 0.86 | ALDH1A1 (0.38) | SPPL2AALDH1A1MEP1BTAS2R14HPGD | |
| SCHEMBL12734840 | 0.86 | SPPL2A (0.44) | SPPL2AALDH1A1LMNAPSEN1PSEN2 | |
| SCHEMBL12734577 | 0.86 | SPPL2A (0.44) | SPPL2AALDH1A1LMNAPSEN1PSEN2 | |
| SCHEMBL12735016 | 0.86 | SPPL2A (0.40) | SPPL2AALDH1A1MEP1BTAS2R14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919523-B2 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS, INC. (US) | 2011-04-05 | — | — | US | disclosed |
| US-20090042973-A1 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042973-A1 | Inhibitors of aspartyl protease | SPINT2, DNPEP, PRSS1 | SPPL2A 93/4885ALDH1A1 1604/4885MEP1B 2332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.