Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1273536 | 1.00 | GRM4 (0.51) | GRM4STAT1IMPDH2MEN1KMT2A | |
| SCHEMBL3858962 | 0.77 | ALDH1A1 (0.50) | MEN1KMT2AMAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL22549232 | 0.76 | GRM4 (0.56) | GRM4MEN1KMT2AMAPTHTT | |
| SCHEMBL29732523 | 0.76 | GRM4 (0.56) | GRM4MEN1KMT2AMAPTHTT | |
| SCHEMBL15972268 | 0.74 | GRM4 (0.59) | GRM4STAT1IMPDH2MEN1KMT2A | |
| SCHEMBL4542071 | 0.74 | GRM4 (0.54) | GRM4STAT1IMPDH2MEN1KMT2A | |
| SCHEMBL4542067 | 0.74 | GRM4 (0.54) | GRM4STAT1IMPDH2MEN1KMT2A | |
| SCHEMBL4542073 | 0.74 | GRM4 (0.54) | GRM4STAT1IMPDH2MEN1KMT2A | |
| SCHEMBL1070868 | 0.74 | GRM4 (0.48) | GRM4IMPDH2MEN1KMT2AMAPT | |
| SCHEMBL1273535 | 0.74 | GRM4 (0.48) | GRM4IMPDH2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879797-B2 | HCV NS3 protease inhibitors | MERCK SHARP & DOHME CORP. (US) | 2011-02-01 | — | — | US | disclosed |