SCHEMBL12740969

SCHEMBL12740969

CCc1ccc(-c2ccc(-c3ccc(COc4ccc(OC)c(F)c4)cc3)c(F)c2F)cc1

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.45
MAPK1 P28482 3/20 0.45
KDM4E B2RXH2 2/20 0.45
FFAR1 O14842 9/20 0.43
PPARD Q03181 7/20 0.43
MAOB P27338 2/20 0.41
PPARA Q07869 2/20 0.41
CYP17A1 P05093 1/20 0.40
POLB P06746 2/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HPGD P15428 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
MGAM O43451 1/20 0.39
GAA P10253 1/20 0.39
SI P14410 1/20 0.39
MGAM2 Q2M2H8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12740525 0.93 FFAR1 (0.45) MAPTMAPK1KDM4EFFAR1PPARD
SCHEMBL10303112 0.92 MAPT (0.47) MAPTMAPK1KDM4EFFAR1PPARD
SCHEMBL12822597 0.92 FFAR1 (0.50) MAPTMAPK1KDM4EFFAR1PPARD
SCHEMBL10303132 0.91 KDM4E (0.44) MAPTMAPK1KDM4EFFAR1PPARD
SCHEMBL12740979 0.90 MAPT (0.47) MAPTMAPK1KDM4EFFAR1PPARD
SCHEMBL12741002 0.90 FFAR1 (0.46) FFAR1PPARDMAOBPPARA
SCHEMBL12740971 0.90 FFAR1 (0.47) MAPTMAPK1KDM4EFFAR1PPARD
SCHEMBL12741006 0.88 FFAR1 (0.47) MAPTMAPK1KDM4EFFAR1PPARD
SCHEMBL12740974 0.87 FFAR1 (0.44) MAPTMAPK1KDM4EFFAR1PPARD
SCHEMBL10302297 0.87 FFAR1 (0.43) MAPTMAPK1KDM4EFFAR1PPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8394294-B2 Four-ring liquid crystal compound having lateral fluorine, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2013-03-12 US disclosed
US-8394294-B2 Four-ring liquid crystal compound having lateral fluorine, liquid crystal composition and liquid crystal display device JNC CORPORATION (JP) 2013-03-12 US disclosed
US-20110090450-A1 FOUR-RING LIQUID CRYSTAL COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2011-04-21 US disclosed
US-20110090450-A1 FOUR-RING LIQUID CRYSTAL COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE JNC CORPORATION (JP) 2011-04-21 US disclosed
WO-2009150966-A1 TETRACYCLIC LIQUID CRYSTALLINE COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY ELEMENT チッソ株式会社 (JP) 2009-12-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110090450-A1 FOUR-RING LIQUID CRYSTAL COMPOUND HAVING LATERAL FLUORINE, LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE LEF1, LAS1L, EFHD2 MAPT 1075/4885MAPK1 529/4885KDM4E 2690/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.