Sugi Predict

Sugi Predict / Targets / LEF1

LEF1

Lymphoid enhancer-binding factor 1 · Q9UJU2 · LEF1 on Sugi Atlas →

311 patent compounds predicted against LEF1, 132 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL6619949 SCHEMBL6619949 0.81 1/20
SCHEMBL6617416 SCHEMBL6617416 0.74 1/20
SCHEMBL29830077 SCHEMBL29830077 0.67 1/20
SCHEMBL20275135 SCHEMBL20275135 0.62 1/20
SCHEMBL3031344 SCHEMBL3031344 0.61 1/20
SCHEMBL19885734 SCHEMBL19885734 0.61 1/20
SCHEMBL3027522 SCHEMBL3027522 0.60 1/20
SCHEMBL3030225 SCHEMBL3030225 0.60 1/20
SCHEMBL5087408 SCHEMBL5087408 0.59 1/20
SCHEMBL13311254 SCHEMBL13311254 0.59 1/20
SCHEMBL5896935 SCHEMBL5896935 0.58 1/20
SCHEMBL6617197 SCHEMBL6617197 0.58 1/20
SCHEMBL6816854 SCHEMBL6816854 0.58 1/20
SCHEMBL3497422 SCHEMBL3497422 0.56 1/20
SCHEMBL20742974 SCHEMBL20742974 0.56 1/20
SCHEMBL29783677 SCHEMBL29783677 0.56 1/20
SCHEMBL5896945 SCHEMBL5896945 0.56 1/20
SCHEMBL5087407 SCHEMBL5087407 0.55 1/20
SCHEMBL7833243 SCHEMBL7833243 0.55 1/20
SCHEMBL14138263 SCHEMBL14138263 0.55 1/20

Clinical trials — most relevant to LEF1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment PHASE2/PHASE3RECRUITING
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized) PHASE3UNKNOWN
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room PHASE2/PHASE3COMPLETED
Evaluation of the Efficacy and Safety of Interleucin-2 Combined With PD-1 Monoclonal Antibody and CAPOX in Preoperative Neoadjuvant Therapy for Mid-low Locally Advanced Rectal Cancer - a Single-center, Single-arm, Open-label Clinical Trail PHASE2COMPLETED
Foxy-5 as Neo-Adjuvant Therapy in Subjects With Wnt-5a Low Colon Cancer PHASE2UNKNOWN
Study of the Beach Regimen on Relapsed/Refractory Acute Myeloid Leukemia (R/R AML) PHASE2ACTIVE_NOT_RECRUITING
EPOCH-R Chemotherapy Plus Bortezomib to Treat Mantle Cell Lymphoma PHASE2COMPLETED
A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL PHASE1/PHASE2RECRUITING
Treatment Duration Increment and Pharmacodynamic Study of CX-4945 in Patients With Basal Cell Carcinoma (BCC) PHASE1COMPLETED
Obinutuzumab in Combination With Venetoclax in Previously Untreated Follicular Lymphoma Patients PHASE1COMPLETED
Study to Evaluate Safety, PK, PD, Immunogenicity & Antitumor Activity of MSC-1 in Patients With Adv Solid Tumors PHASE1COMPLETED
Study on the Safety and Tolerability of PD-1 Knockout Tumor-infiltrating T Cells (TILs) in the Treatment of Advanced Colorectal Cancer PHASE1RECRUITING
LEF1 EXPRESSION IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: A MARKER FOR DIAGNOSIS AND SURVIVAL PREDICTION nanRECRUITING
A Case Control Study of Resveratrol Effects in Coronary Artery Disease Patients With Metabolic Syndrome nanCOMPLETED
Peripheral Blood Stem Cells Obtained From Normal Volunteers for Studying Retroviral Vector Mediated Gene Transfer Into Primitive Hematopoietic Cells and Vector Mediated Transgene Expression in Mature Hematopoietic Lineages nanCOMPLETED
Card14gene (rs34367357 ) Polymorphism in Egyptian Psoriatic and Psoriatic Arthritis Patient nanRECRUITING
C-X-C Chemokine Receptor 4 in Chronic Lymphocytic Leukemia nanUNKNOWN
Study of Proteins in Head and Neck Cancer Cells nanCOMPLETED
Model to Predict pCR and IrAEs in Early Stage Non-small Cell Lung Cancer nanUNKNOWN
Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study nanUNKNOWN
RORC Genetic Polymorphism of Rheumatoid Arthritis nanCOMPLETED
Detection of IKZF1 Deletion Mutation in Patients With Acute Lymphoblastic Leukemia and Its Impact in Therapy nanUNKNOWN
Studying Dexamethasone and Prednisone Sensitivity in Samples From Younger Patients With High-Risk B-Cell Precursor Acute Lymphoblastic Leukemia nanCOMPLETED
New Biomarkers for Diagnosis and Follow-up of Patients With LRBA or CTLA4 Deficiencies nanUNKNOWN
Omega-3 to Reduce Diabetes Risk in Subjects With High Number of Particles That Carry Bad Cholesterol in the Blood nanCOMPLETED
Feasibility Trial of Preoperative 5-Day Hypofractionated Radiotherapy for Primary Soft Tissue Sarcoma nanACTIVE_NOT_RECRUITING
EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors nanUNKNOWN
Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood Acute Lymphoblastic Leukemia of T Cells. nanUNKNOWN
Studying Genes in Samples From Younger Patients With Relapsed Acute Lymphoblastic Leukemia nanCOMPLETED
MIF Involvement in AML nanACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a LEF1 binder may also engage these)

ProteinNameSimilarity
Q9QXN1 — 1.000 Q9QXN1 →
P27782 — 1.000 P27782 →
Q66JW3 — 1.000 Q66JW3 →
Q3V5Z9 — 1.000 Q3V5Z9 →
Q90XW5 — 1.000 Q90XW5 →
P23682 — 0.999 P23682 →
Q5U4X3 — 0.999 Q5U4X3 →
O55170 — 0.999 O55170 →
Q6VVD7 — 0.999 Q6VVD7 →
Q28EM1 — 0.999 Q28EM1 →
Q9DE25 — 0.999 Q9DE25 →
A4IIJ8 — 0.998 A4IIJ8 →
Q9PVY9 — 0.998 Q9PVY9 →
P23773 — 0.998 P23773 →
P50574 — 0.998 P50574 →
P40645 — 0.998 P40645 →
P50576 — 0.998 P50576 →
Q04888 — 0.998 Q04888 →
Q9BG89 — 0.998 Q9BG89 →
P48436 — 0.998 P48436 →
P61753 — 0.998 P61753 →
Q9PVZ3 — 0.998 Q9PVZ3 →
Q1KKW8 — 0.998 Q1KKW8 →
Q1KL13 — 0.997 Q1KL13 →
O42342 — 0.997 O42342 →
P22199 — 0.997 P22199 →
Q7YRJ7 — 0.997 Q7YRJ7 →
Q6DFF5 — 0.997 Q6DFF5 →
O94900 — 0.997 O94900 →
Q91904 — 0.997 Q91904 →