Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 17/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1459697 | 0.84 | CYP1A1 (0.51) | ABCB1ORAI1ALDH1A1 | |
| SCHEMBL1459974 | 0.79 | ROCK2 (0.42) | ROCK2ROCK1ORAI1ALDH1A1 | |
| SCHEMBL1458977 | 0.78 | MAPK14 (0.41) | ROCK2ROCK1ORAI1ALDH1A1 | |
| SCHEMBL1459687 | 0.77 | ORAI1 (0.52) | ABCB1ORAI1 | |
| SCHEMBL1459868 | 0.77 | KDM4E (0.49) | ABCB1ORAI1ALDH1A1 | |
| SCHEMBL1459748 | 0.77 | FFAR1 (0.42) | — | |
| SCHEMBL12825551 | 0.76 | ORAI1 (0.52) | ROCK2ROCK1ABCB1ORAI1ALDH1A1 | |
| SCHEMBL1459509 | 0.76 | ORAI1 (0.41) | ABCB1ORAI1 | |
| SCHEMBL1458818 | 0.75 | KDM4E (0.49) | ORAI1ALDH1A1 | |
| SCHEMBL1460929 | 0.74 | ORAI1 (0.49) | ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071150-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | ALAM MUZAFFAR | 2011-03-24 | — | — | US | disclosed |
| US-20110071150-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | ALAM MUZAFFAR | 2011-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071150-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | ORAI1, RYR2, CACNA1E | ROCK2 860/4885ROCK1 688/4885ABCB1 1106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.