Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 12/20 | 0.91 |
| ▸ | CDK2 | P24941 | 9/20 | 0.91 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.57 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.57 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.57 |
| ▸ | JAK1 | P23458 | 8/20 | 0.56 |
| ▸ | TYK2 | P29597 | 8/20 | 0.56 |
| ▸ | JAK3 | P52333 | 6/20 | 0.56 |
| ▸ | JAK2 | O60674 | 5/20 | 0.56 |
| ▸ | CDK4 | P11802 | 2/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.56 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.56 |
| ▸ | CCND1 | P24385 | 2/20 | 0.56 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.56 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.56 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.56 |
| ▸ | GSK3A | P49840 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4156172 | 0.95 | CDK1 (1.00) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL12755105 | 0.92 | CDK1 (0.90) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL12755099 | 0.89 | CDK1 (0.76) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL12755104 | 0.87 | CDK1 (0.74) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL12755112 | 0.87 | CDK1 (0.75) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL12755095 | 0.87 | CDK1 (0.88) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL12755102 | 0.86 | CDK1 (0.80) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL12755106 | 0.85 | CDK1 (0.92) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL12755109 | 0.85 | CDK1 (0.72) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL12893413 | 0.83 | CDK1 (0.83) | CDK1CDK2CCNB2CCNB1CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299082-B2 | 1,2,4-triazolylaminoaryl (heteroaryl) sulfonamide derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2012-10-30 | — | — | US | disclosed |
| US-20110077249-A1 | 1,2,4-TRIAZOLYLAMINOARYL (HETEROARYL) SULFONAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077249-A1 | 1,2,4-TRIAZOLYLAMINOARYL (HETEROARYL) SULFONAMIDE DERIVATIVES | CCNI, CCNA2, CCNA1 | CDK1 42/4885CDK2 7/4885CCNB2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.