Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 10/20 | 1.00 |
| ▸ | CDK2 | P24941 | 8/20 | 1.00 |
| ▸ | JAK1 | P23458 | 10/20 | 0.62 |
| ▸ | TYK2 | P29597 | 10/20 | 0.62 |
| ▸ | JAK3 | P52333 | 7/20 | 0.62 |
| ▸ | JAK2 | O60674 | 6/20 | 0.62 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.62 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | STK25 | O00506 | 1/20 | 0.62 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.62 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.62 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12755100 | 0.95 | CDK1 (0.91) | CDK1CDK2JAK1TYK2JAK3 | |
| SCHEMBL12893413 | 0.88 | CDK1 (0.83) | CDK1CDK2JAK1TYK2JAK3 | |
| SCHEMBL12755105 | 0.87 | CDK1 (0.90) | CDK1CDK2JAK1TYK2JAK3 | |
| SCHEMBL4145390 | 0.86 | CDK1 (1.00) | CDK1CDK2JAK1TYK2JAK3 | |
| SCHEMBL4163080 | 0.84 | CDK1 (0.90) | CDK1CDK2JAK1TYK2JAK3 | |
| SCHEMBL4157634 | 0.84 | CDK1 (0.80) | CDK1CDK2JAK1TYK2JAK3 | |
| SCHEMBL4159410 | 0.83 | CDK1 (1.00) | CDK1CDK2JAK1TYK2JAK3 | |
| SCHEMBL12755099 | 0.83 | CDK1 (0.76) | CDK1CDK2JAK1TYK2JAK3 | |
| SCHEMBL12755104 | 0.82 | CDK1 (0.74) | CDK1CDK2JAK1TYK2JAK3 | |
| SCHEMBL12755112 | 0.81 | CDK1 (0.75) | CDK1CDK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7888380-B2 | 1,2,4-Triazolylaminoaryl (heteroaryl) sulfonamide derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2011-02-15 | — | — | US | disclosed |
| EP-1797049-A4 | 1,2,4-TRIAZOLYLAMINOARYL (HETEROARYL) SULFONAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-17 | — | — | EP | disclosed |
| EP-1797049-A1 | 1,2,4-TRIAZOLYLAMINOARYL (HETEROARYL) SULFONAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006042215-A1 | 1,2,4-TRIAZOLYLAMINOARYL (HETEROARYL) SULFONAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-04-20 | — | — | WO | disclosed |