Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | IL2 | P60568 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14351749 | 0.89 | KDM4E (0.59) | KDM4EATMHTTALDH1A1HPGD | |
| SCHEMBL9842227 | 0.84 | ATM (0.56) | KDM4EATMHTTALDH1A1HPGD | |
| SCHEMBL8488769 | 0.79 | KDM4E (0.49) | KDM4EATMHTTALDH1A1HPGD | |
| SCHEMBL18380643 | 0.78 | KDM4E (0.61) | KDM4EATMHTTALDH1A1HPGD | |
| SCHEMBL6850657 | 0.78 | KDM4E (0.53) | KDM4EATMHTTALDH1A1HPGD | |
| SCHEMBL31542580 | 0.78 | KDM4E (0.53) | KDM4EATMHTTALDH1A1HPGD | |
| SCHEMBL1535944 | 0.77 | KDM4E (0.53) | KDM4EATMHTTALDH1A1HPGD | |
| SCHEMBL9054634 | 0.76 | KDM4E (0.44) | KDM4EATMHTTALDH1A1HPGD | |
| SCHEMBL10746575 | 0.76 | KDM4E (0.51) | KDM4EATMHTTALDH1A1HPGD | |
| SCHEMBL22051496 | 0.76 | KDM4E (0.51) | KDM4EATMHTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2286811-A1 | Chemokine receptor antagonists and methods of use thereof | Millennium Pharmaceuticals, Inc. (US) | 2011-02-23 | — | — | EP | disclosed |