SCHEMBL1276353

SCHEMBL1276353

C=CCOC(=O)CNCC(=O)OCC=C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.47
TDP1 Q9NUW8 1/20 0.43
MAPT P10636 1/20 0.42
CACNA1B Q00975 1/20 0.42
APBA1 Q02410 1/20 0.42
CYP3A4 P08684 1/20 0.41
ALDH1A1 P00352 4/20 0.40
GAA P10253 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
PKM P14618 1/20 0.39
LMNA P02545 1/20 0.36
HSD17B10 Q99714 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
EPHX2 P34913 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.33
CASP1 P29466 1/20 0.32
SNCA P37840 1/20 0.32
APP P05067 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10454578 0.96 TSHR (0.44) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL1162364 0.92 TSHR (0.42) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL29152953 0.92 TSHR (0.46) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL8824241 0.87 TSHR (0.50) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL89278 0.86 TSHR (0.41) TSHRTDP1MAPTCACNA1BAPBA1
Silicate SCHEMBL11879531 0.85 TSHR (0.38) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL7111318 0.85 TSHR (0.43) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL8824208 0.84 TSHR (0.51) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL1161936 0.82 TSHR (0.42) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL1368224 0.82 TDP1 (0.39) TSHRTDP1MAPTCACNA1BAPBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118338783-A Composition for controlling arthropods 宝洁公司 2024-07-12 CN disclosed
US-20220228067-A1 SURFACTANT COMPOSITION FOR FOAMING SAND NOF CORPORATION (JP) 2022-07-21 US disclosed
EP-3981525-A1 SURFACTANT COMPOSITION FOR FOAMING SAND NOF Corporation (JP) 2022-04-13 EP disclosed
US-11197807-B2 Gel-type oil-in-water emulsion composition FUJIFILM CORPORATION (JP) 2021-12-14 US disclosed
EP-3613408-B1 GEL TYPE OIL-IN-WATER EMULSION COMPOSITION FUJIFILM CORP (JP) 2021-02-24 EP disclosed
EP-3613408-A1 OIL-IN-WATER EMULSION COMPOSITION GEL FUJIFILM Corporation (JP) 2020-02-26 EP disclosed
US-20200046615-A1 GEL-TYPE OIL-IN-WATER EMULSION COMPOSITION FUJIFILM CORPORATION (JP) 2020-02-13 US disclosed
US-8901072-B2 Glycopeptide and lipoglycopeptide antibiotics with improved solubility THE MEDICINES COMPANY (US) 2014-12-02 US disclosed
US-20120149632-A1 GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS WITH IMPROVED SOLUBILITY THE MEDICINES COMPANY (US) 2012-06-14 US disclosed
WO-2011019839-A2 GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS WITH IMPROVED SOLUBILITY THE MEDICINES COMPANY (US) 2011-02-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120149632-A1 GLYCOPEPTIDE AND LIPOGLYCOPEPTIDE ANTIBIOTICS WITH IMPROVED SOLUBILITY NGLY1, LGALS3BP, GYPA TSHR 3204/4885TDP1 3648/4885MAPT 4770/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.