SCHEMBL89278

SCHEMBL89278

C=CCOC(=O)CNCCO

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.41
TDP1 Q9NUW8 1/20 0.38
MAPT P10636 1/20 0.37
CACNA1B Q00975 1/20 0.37
APBA1 Q02410 1/20 0.37
ALDH1A1 P00352 4/20 0.36
GAA P10253 1/20 0.36
CYP3A4 P08684 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
PKM P14618 1/20 0.34
CASP1 P29466 2/20 0.34
EPHX2 P34913 1/20 0.34
MAPK1 P28482 1/20 0.33
LMNA P02545 2/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
HSD17B10 Q99714 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10454578 0.86 TSHR (0.44) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL1276353 0.86 TSHR (0.47) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL8824208 0.83 TSHR (0.51) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL1161936 0.81 TSHR (0.42) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL8824252 0.80 TSHR (0.57) TSHRTDP1ALDH1A1GAACASP1
SCHEMBL8627637 0.80 MAOA (0.42) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL24703558 0.79 TDP1 (0.41) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL6677773 0.79 TSHR (0.44) TSHRTDP1MAPTCACNA1BAPBA1
SCHEMBL18741294 0.79 TSHR (0.60) TSHRTDP1ALDH1A1GAASMN1; SMN2
SCHEMBL8824241 0.78 TSHR (0.50) TSHRTDP1MAPTCACNA1BAPBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104585228-A MITIGATING NECROSIS IN TRANSGENIC GLYPHOSATE-TOLERANT COTTON PLANTS TREATED WITH HERBICIDAL GLYPHOSATE FORMULATIONS MONSANTO TECHNOLOGY LLC 2015-05-06 CN claimed
EP-1853115-A2 MITIGATING NECROSIS IN TRANSGENIC GLYPHOSATE-TOLERANT COTTON PLANTS TREATED WITH HERBICIDAL GLYPHOSATE FORMULATIONS Monsanto Technology, LLC (US) 2007-11-14 EP claimed
WO-2006096617-A2 MITIGATING NECROSIS IN TRANSGENIC GLYPHOSATE-TOLERANT COTTON PLANTS TREATED WITH HERBICIDAL GLYPHOSATE FORMULATIONS MONSANTO TECHNOLOGY LLC (US) 2006-09-14 WO claimed
US-20230102424-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations MONSANTO TECHNOLOGY LLC 2023-03-30 US disclosed
US-20200236930-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations MONSANTO TECHNOLOGY LLC (US) 2020-07-30 US disclosed
EP-1853115-B1 MITIGATING NECROSIS IN TRANSGENIC GLYPHOSATE-TOLERANT COTTON PLANTS TREATED WITH HERBICIDAL GLYPHOSATE FORMULATIONS MONSANTO TECHNOLOGY LLC (US) 2019-01-09 EP disclosed
US-20170339950-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations MONSANTO TECHNOLOGY LLC (US) 2017-11-30 US disclosed
CN-104585228-B Mitigating necrosis in transgenic glyphosate-tolerant cotton plants treated with herbicidal glyphosate formulations 孟山都技术公司 2017-05-24 CN disclosed
US-9642359-B2 Mitigating necrosis in transgenic glyphosate-tolerant cotton plants treated with herbicidal glyphosate formulations MONSANTO TECHNOLOGY LLC (US) 2017-05-09 US disclosed
US-20160330956-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations MONSANTO TECHNOLOGY LLC (US) 2016-11-17 US disclosed
US-9364003-B2 Mitigating necrosis in transgenic glyphosate-tolerant cotton plants treated with herbicidal glyphosate formulations MONSANTO TECHNOLOGY LLC (US) 2016-06-14 US disclosed
CN-104585228-A MITIGATING NECROSIS IN TRANSGENIC GLYPHOSATE-TOLERANT COTTON PLANTS TREATED WITH HERBICIDAL GLYPHOSATE FORMULATIONS MONSANTO TECHNOLOGY LLC 2015-05-06 CN disclosed
CN-102792969-B Mitigating necrosis in transgenic glyphosate-tolerant cotton plants treated with herbicidal glyphosate formulations MONSANTO TECHNOLOGY LLC 2015-01-21 CN disclosed
US-20120149569-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations MONSANTO TECHNOLOGY LLC (US) 2012-06-14 US disclosed
US-8129564-B2 Mitigating necrosis in transgenic glyphosate-tolerant cotton plants treated with herbicidal glyphosate formulations MONSANTO TECHNOLOGY LLC (US) 2012-03-06 US disclosed
EP-1853115-A2 MITIGATING NECROSIS IN TRANSGENIC GLYPHOSATE-TOLERANT COTTON PLANTS TREATED WITH HERBICIDAL GLYPHOSATE FORMULATIONS Monsanto Technology, LLC (US) 2007-11-14 EP disclosed
US-20070037708-A1 Mitigating necrosis in transgenic glyphosate-tolerant cotton plants treated with herbicidal glyphosate formulations MONSANTO TECHNOLOGY, LLC (US) 2007-02-15 US disclosed
WO-2006096617-A2 MITIGATING NECROSIS IN TRANSGENIC GLYPHOSATE-TOLERANT COTTON PLANTS TREATED WITH HERBICIDAL GLYPHOSATE FORMULATIONS MONSANTO TECHNOLOGY LLC (US) 2006-09-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200236930-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations GLO1, AGXT, GRHPR TSHR 2627/4885TDP1 681/4885MAPT 2738/4885
US-20070037708-A1 Mitigating necrosis in transgenic glyphosate-tolerant cotton plants treated with herbicidal glyphosate formulations GLO1, AGXT, GRHPR TSHR 2627/4885TDP1 681/4885MAPT 2738/4885
US-20170339950-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations GLO1, AGXT, GRHPR TSHR 2627/4885TDP1 681/4885MAPT 2738/4885
US-20120149569-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations GLO1, AGXT, GRHPR TSHR 2627/4885TDP1 681/4885MAPT 2738/4885
US-20230102424-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations GLO1, AGXT, GRHPR TSHR 2627/4885TDP1 681/4885MAPT 2738/4885
US-20160330956-A1 Mitigating Necrosis in Transgenic Glyphosate-Tolerant Cotton Plants Treated with Herbicidal Glyphosate Formulations GLO1, AGXT, GRHPR TSHR 2627/4885TDP1 681/4885MAPT 2738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.