Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13130530 | 0.91 | BRAF (0.60) | BRAFMAPK14 | |
| SCHEMBL1936141 | 0.91 | BRAF (0.60) | BRAFMAPK14 | |
| SCHEMBL10104561 | 0.90 | BRAF (0.59) | BRAFMAPK14 | |
| SCHEMBL13130531 | 0.89 | BRAF (0.58) | BRAFMAPK14 | |
| SCHEMBL5010295 | 0.89 | MAPK14 (0.61) | BRAFMAPK14 | |
| SCHEMBL5163836 | 0.89 | BRAF (0.62) | BRAFMAPK14 | |
| SCHEMBL13130507 | 0.88 | BRAF (0.57) | BRAFMAPK14 | |
| SCHEMBL13130304 | 0.88 | BRAF (0.57) | BRAFMAPK14 | |
| SCHEMBL10104560 | 0.87 | BRAF (0.56) | BRAFMAPK14 | |
| SCHEMBL13130511 | 0.85 | BRAF (0.55) | BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906522-B2 | 2-aminoquinazoline derivatives | KYOWA HAKKO KIRIN CO., LTD (JP) | 2011-03-15 | — | — | US | disclosed |
| US-20090137583-A1 | 2-AMINOQUINAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137583-A1 | 2-AMINOQUINAZOLINE DERIVATIVES | SLC7A1, SLC38A7, PRMT7 | BRAF 1985/4885MAPK14 1725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.