Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 16/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 15/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1276370 | 0.89 | ADRB2 (0.59) | CHRM3CHRM2ADRB2ADRB1DRD2 | |
| SCHEMBL10241950 | 0.83 | ADRB2 (0.62) | CHRM3CHRM2ADRB2ADRB1DRD2 | |
| SCHEMBL10241654 | 0.83 | ADRB2 (0.67) | CHRM3CHRM2ADRB2ADRB1DRD2 | |
| SCHEMBL10242177 | 0.80 | ADRB2 (0.63) | CHRM3CHRM2ADRB2ADRB1DRD2 | |
| SCHEMBL10242147 | 0.80 | ADRB2 (0.63) | CHRM3CHRM2ADRB2ADRB1DRD2 | |
| SCHEMBL10242161 | 0.80 | ADRB2 (0.61) | CHRM3CHRM2ADRB2ADRB1DRD2 | |
| SCHEMBL10241948 | 0.79 | ADRB2 (0.68) | CHRM3CHRM2ADRB2ADRB1DRD2 | |
| SCHEMBL1276054 | 0.79 | ADRB2 (0.81) | CHRM3CHRM2ADRB2ADRB1DRD2 | |
| SCHEMBL1276374 | 0.79 | ADRB2 (0.81) | CHRM3CHRM2ADRB2ADRB1DRD2 | |
| SCHEMBL10242150 | 0.79 | ADRB2 (0.59) | CHRM3CHRM2ADRB2ADRB1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2398792-A1 | TOSYLATE SALT OF A 5-PYRAZOLYL-2-PYRIDONE DERIVATIVE, USEFUL IN THE TREATMENT OF COPD | AstraZeneca AB (SE) | 2011-12-28 | — | — | EP | disclosed |
| WO-2011012897-A1 | NEW COMBINATIONS FOR THE TREATMENT OF ASTHMA | ASTRAZENECA AB (SE) | 2011-02-03 | — | — | WO | disclosed |
| EP-2242759-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2010-10-27 | — | — | EP | disclosed |
| WO-2010094964-A1 | TOSYLATE SALT OF A 5-PYRAZOLYL-2-PYRIDONE DERIVATIVE, USEFUL IN THE TREATMENT OF COPD | ASTRAZENECA AB (SE) | 2010-08-26 | — | — | WO | disclosed |
| WO-2009098448-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2009-08-13 | — | — | WO | disclosed |