Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | IDE | P14735 | 1/20 | 0.69 |
| ▸ | MPI | P34949 | 1/20 | 0.69 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.69 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.69 |
| ▸ | DAO | P14920 | 1/20 | 0.62 |
| ▸ | DDO | Q99489 | 1/20 | 0.62 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.54 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.54 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.54 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.54 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.54 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | PARP1 | P09874 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TNKS | O95271 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1884123 | 0.82 | KDM4E (1.00) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL15690621 | 0.78 | KDM4E (0.71) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL11229455 | 0.77 | KDM4E (0.69) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL31175987 | 0.77 | KDM4E (0.53) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL3360017 | 0.77 | DAO (1.00) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL17942038 | 0.77 | KDM4E (0.69) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL29314622 | 0.77 | DAO (0.58) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL23350310 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL5027261 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1MAPTIDEMPI | |
| SCHEMBL9390003 | 0.76 | KDM4E (0.67) | KDM4EALDH1A1MAPTIDEMPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279736-A1 | Microbicidal and antiparasitic compositions comprising quassinoids or quassionid-containing plant extracts | Life Science Investments Ltd. (GB) | 2011-02-02 | — | — | EP | claimed |
| US-8865235-B2 | Microbicidal and antiparasitic compositions | Life Science Investments, Ltd. (GB) | 2014-10-21 | — | — | US | disclosed |
| US-20140005259-A1 | MICROBICIDAL AND ANTIPARASITIC COMPOSITIONS | LIFE SCIENCE INVESTMENTS LIMITED (GB) | 2014-01-02 | — | — | US | disclosed |
| US-8568794-B2 | Topical and intravaginal microbicidal and antiparasitic compositions comprising quassinoids or quassinoid-containing plant extracts | Life Science Investments, Ltd. (GB) | 2013-10-29 | — | — | US | disclosed |
| EP-2279736-A1 | Microbicidal and antiparasitic compositions comprising quassinoids or quassionid-containing plant extracts | Life Science Investments Ltd. (GB) | 2011-02-02 | — | — | EP | disclosed |
| US-20080089958-A1 | Dermo-cosmetic compositions for topical and intravaginal application for treatment of human and veterinary affections caused by anaerobic organisms; vaginitis | LIFE SCIENCE INVESTMENTS LIMITED (GB) | 2008-04-17 | — | — | US | disclosed |
| EP-1758576-A1 | TOPICAL AND INTRAVAGINAL MICROBICIDAL AND ANTIPARASITIC COMPOSITIONS COMPRISING QUASSINOIDS OR QUASSIONID-CONTAINING PLANT EXTRACTS | Diehl, Christian (ES) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005092329-A1 | TOPICAL AND INTRAVAGINAL MICROBICIDAL ANTIPARASITIC COMPOSITIONS COMPRISING QUASSINOIDS OR QUASSINOID-CONTAINING PLANT EXTRACTS | DIEHL CHRISTIAN (AR) | 2005-10-06 | — | — | WO | disclosed |