Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | P4HB | P07237 | 1/20 | 0.34 |
| ▸ | PDIA4 | P13667 | 1/20 | 0.34 |
| ▸ | PDIA3 | P30101 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767576 | 0.87 | TSHR (0.39) | TSHRL3MBTL1ELANELMNACYP3A4 | |
| SCHEMBL2741355 | 0.86 | LMNA (0.39) | TSHRL3MBTL1ELANELMNACYP3A4 | |
| SCHEMBL2741349 | 0.86 | LMNA (0.46) | TSHRLMNACYP3A4ALDH1A1MAPT | |
| SCHEMBL15061506 | 0.85 | TSHR (0.54) | TSHRLMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL4178413 | 0.85 | TSHR (0.54) | TSHRLMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL4178428 | 0.85 | TSHR (0.54) | TSHRLMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL1527148 | 0.85 | TSHR (0.54) | TSHRLMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL16328963 | 0.85 | TSHR (0.54) | TSHRLMNATHRBSMN1; SMN2HIF1A | |
| SCHEMBL15338605 | 0.81 | LMNA (0.48) | TSHRLMNACYP2D6THRBSMN1; SMN2 | |
| SCHEMBL6553250 | 0.80 | TNF (0.42) | TSHRLMNAALDH1A1CYP2D6PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160279248-A1 | EXTRACELLULAR TARGETED DRUG CONJUGATES | CENTROSE, LLC | 2016-09-29 | — | — | US | disclosed |
| US-9364554-B2 | Extracellular targeted drug conjugates | CENTROSE LLC (US) | 2016-06-14 | — | — | US | disclosed |
| US-8470980-B2 | Extracellular targeted drug conjugates | CENTROSE, LLC (US) | 2013-06-25 | — | — | US | disclosed |
| US-20110064752-A1 | EXTRACELLULAR TARGETED DRUG CONJUGATES | CENTROSE, LLC (US) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110064752-A1 | EXTRACELLULAR TARGETED DRUG CONJUGATES | FCGR2A, ENGASE, FCER2 | TSHR 929/4885L3MBTL1 3401/4885ELANE 75/4885 |
| US-20160279248-A1 | EXTRACELLULAR TARGETED DRUG CONJUGATES | FCGR2A, ENGASE, FCER2 | TSHR 929/4885L3MBTL1 3401/4885ELANE 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.