Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | AGXT | P21549 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 6/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12769262 | 0.86 | GLA (0.39) | GLANPSR1PPARGTDP1L3MBTL1 | |
| SCHEMBL12769950 | 0.86 | GLA (0.39) | GLANPSR1PPARGTDP1L3MBTL1 | |
| SCHEMBL12769967 | 0.85 | TDP1 (0.40) | GLANPSR1PPARGTDP1L3MBTL1 | |
| SCHEMBL17082370 | 0.81 | CYP3A4 (0.39) | GLANPSR1PPARGTDP1L3MBTL1 | |
| SCHEMBL14212905 | 0.79 | TDP1 (0.36) | GLANPSR1PPARGTDP1L3MBTL1 | |
| SCHEMBL14212903 | 0.79 | TDP1 (0.36) | GLANPSR1PPARGTDP1L3MBTL1 | |
| SCHEMBL12769963 | 0.78 | HDAC4 (0.36) | GLANPSR1PPARGTDP1L3MBTL1 | |
| SCHEMBL14212904 | 0.78 | TDP1 (0.35) | GLANPSR1PPARGTDP1L3MBTL1 | |
| SCHEMBL8074066 | 0.76 | TDP1 (0.42) | PPARGTDP1L3MBTL1IDO1AGXT | |
| SCHEMBL8074069 | 0.76 | TDP1 (0.42) | PPARGTDP1L3MBTL1IDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915306-B2 | For therapy of inflammatory or autoimmune disorders | EISAI CO., LTD. (JP) | 2011-03-29 | — | — | US | disclosed |
| US-7799827-B2 | Macrocyclic compounds useful as pharmaceuticals | EISAI CO., LTD. (JP) | 2010-09-21 | — | — | US | disclosed |