SCHEMBL1277131

SCHEMBL1277131

CCOC(=O)C=CC(=O)OO

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HCAR2 Q8TDS4 4/20 0.67
▸ MAPT P10636 6/20 0.48
▸ ATM Q13315 1/20 0.48
▸ NPSR1 Q6W5P4 1/20 0.46
▸ CA12 O43570 1/20 0.46
▸ CA1 P00915 1/20 0.46
▸ CA2 P00918 1/20 0.46
▸ CA7 P43166 1/20 0.46
▸ CA9 Q16790 1/20 0.46
▸ CA14 Q9ULX7 1/20 0.46
▸ ALDH1A1 P00352 3/20 0.43
▸ LMNA P02545 3/20 0.43
▸ MDM2 Q00987 2/20 0.43
▸ TTR P02766 1/20 0.42
▸ DPP4 P27487 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ ALOX15 P16050 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ MGAM O43451 1/20 0.40
▸ GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1277278 1.00 HCAR2 (0.67) HCAR2MAPTATMNPSR1CA12
SCHEMBL1277129 1.00 HCAR2 (0.67) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL28432840 0.90 HCAR2 (0.73) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL60423 0.89 HCAR2 (0.80) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL42602 0.89 HCAR2 (0.80) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL27966383 0.89 HCAR2 (0.80) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL2015895 0.89 HCAR2 (0.80) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL2015896 0.89 HCAR2 (0.80) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL43033 0.89 HCAR2 (0.80) HCAR2MAPTATMNPSR1CA12
Diethyl Maleate SCHEMBL8935022 0.87 HCAR2 (0.76) HCAR2MAPTATMNPSR1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1988066-B1 Binding of fibrous material utilizing a crosslinked polyamic acid JOHNS MANVILLE (US) 2020-06-03 — — EP disclosed
US-8652579-B2 Processes of making fiber-containing composites from polyamic acid-containing binder compositions JOHNS MANVILLE (US) 2014-02-18 — — US disclosed
US-8357746-B2 Joining fibers; formaldehyde-free; esterification of michael adduct containing hydroxyl groups and acid; cured waterproof binder ; for glass fiber insulation construction materials JOHNS MANVILLE (US) 2013-01-22 — — US disclosed
US-20120088032-A1 BUSINESS METHOD FOR BUILDING PERFORMANCE RETROFIT OF EXISTING SINGLE FAMILY RESIDENTIAL HOMES JOHNS MANVILLE 2012-04-12 — — US disclosed
US-7825214-B2 Purified styrene-maleic anhydride polymer binder JOHNS MANVILLE (US) 2010-11-02 — — US disclosed
EP-2083021-A1 Purified styrene-maleic anhydride polymer binder Johns Manville (US) 2009-07-29 — — EP disclosed
US-20090182108-A1 Purified styrene-maleic anhydride polymer binder JOHNS MANVILLE 2009-07-16 — — US disclosed
US-20080274291-A1 Binding of fibrous material utilizing a water soluble Michael adduct crosslinking agent and polycarboxylic acid JOHNS MANVILLE 2008-11-06 — — US disclosed
US-20080274292-A1 Binding of fibrous material utilizing a crosslinked polyamic acid JOHNS MANVILLE 2008-11-06 — — US disclosed
EP-1988066-A2 Binding of fibrous material utilizing a crosslinked polyamic acid Johns Manville (US) 2008-11-05 — — EP disclosed
US-5907023-A ACRYLATED POLYETHERURETHANE ADDITION-CONDENSATION COPOLYMER PROTECTIVE COATINGS HAVING A HIGH REFRACTIVE INDEX AND GOOD RESISTANCE TO COLOR CHANGE, AND AN IMPROVED RESISTANCE TO SOLVENT, WATERPROOFING DSM NV (NL) 1999-05-25 — — US disclosed
EP-0794971-B1 OPTICAL GLASS FIBER COATED WITH A RADIATION-CURABLE COATING COMPOSITION DSM NV (NL) 1999-01-13 — — EP disclosed
EP-0794971-A1 RADIATION-CURABLE COATING COMPOSITION AND COATING DSM N.V. (NL) 1997-09-17 — — EP disclosed
WO-1996017000-A1 RADIATION-CURABLE COATING COMPOSITION AND COATING DSM N.V. (NL) 1996-06-06 — — WO disclosed
US-4617343-A ACRYLIC RESINS INCLUDING SULFO UNSATURATED MONOMERS; ALCOHOL-DILUTABLE; NONSMEARING OF PRINTER SURFACES NATIONAL STARCH AND CHEMICAL CORPORATION (US) 1986-10-14 — — US disclosed
US-4130518-A Preparation of acrylated or methacrylated polymers utilizing a partially solubilized hydrocarbon fraction as the azeotroping medium CELANESE CORPORATION (US) 1978-12-19 — — US disclosed
US-4045462-A POLYURETHANES BAYER AKTIENGESELLSCHAFT (DT) 1977-08-30 — — US disclosed
US-4035321-A Preparation of ultraviolet curable acrylated polymers CELANESE CORPORATION (US) 1977-07-12 — — US disclosed
US-3962161-A CROSSLINKING OF DIOLEFINIC POLYMERS USING DIACYL NITRILE OXIDES CELANESE CORPORATION (US) 1976-06-08 — — US disclosed
Send feedback