Diethyl Maleate

Diethyl Maleate

SCHEMBL60423

CCOC(=O)/C=C\C(=O)OCC

nearest known ligand 0.80

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 5/20 0.80
ATM Q13315 1/20 0.56
MAPT P10636 4/20 0.56
NPSR1 Q6W5P4 1/20 0.54
ALDH1A1 P00352 3/20 0.53
CA12 O43570 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
LMNA P02545 2/20 0.50
HSD17B10 Q99714 1/20 0.50
MDM2 Q00987 1/20 0.48
ALOX15 P16050 1/20 0.48
MGAM O43451 1/20 0.48
GAA P10253 1/20 0.48
SI P14410 1/20 0.48
MGAM2 Q2M2H8 1/20 0.48
SOAT1 P35610 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diethyl Maleate SCHEMBL42602 1.00 HCAR2 (0.80) HCAR2ATMMAPTNPSR1ALDH1A1
Diethyl Maleate SCHEMBL43033 1.00 HCAR2 (0.80) HCAR2ATMMAPTNPSR1ALDH1A1
Diethyl Maleate SCHEMBL2015895 1.00 HCAR2 (0.80) HCAR2ATMMAPTNPSR1ALDH1A1
Diethyl Maleate SCHEMBL27966383 1.00 HCAR2 (0.80) HCAR2ATMMAPTNPSR1ALDH1A1
Diethyl Maleate SCHEMBL2015896 1.00 HCAR2 (0.80) HCAR2ATMMAPTNPSR1ALDH1A1
Diethyl Maleate SCHEMBL138683 0.97 HCAR2 (0.76) HCAR2ATMMAPTNPSR1ALDH1A1
Diethyl Maleate SCHEMBL135447 0.97 HCAR2 (0.76) HCAR2ATMMAPTNPSR1ALDH1A1
Diethyl Maleate SCHEMBL8935022 0.97 HCAR2 (0.76) HCAR2ATMMAPTNPSR1ALDH1A1
Diethyl Maleate SCHEMBL4942417 0.97 HCAR2 (0.76) HCAR2ATMMAPTNPSR1ALDH1A1
Diethyl Maleate SCHEMBL28377914 0.97 HCAR2 (0.76) HCAR2ATMMAPTNPSR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 32757 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117264159-B Preparation method and application of anionic water-based polyaspartic acid ester resin ZHEJIANG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2026-05-26 CN claimed
CN-116917446-B Hydroprocessing process using catalyst sequences with nickel, molybdenum and tungsten based catalysts IFP Energies Nouvelles (FR) 2026-05-26 CN claimed
CN-122057087-A High-strength degradable lung sealing agent and preparation process thereof 广州迅合医疗科技有限公司 2026-05-19 CN claimed
US-12629669-B2 Method for rejuvenating a catalyst from a hydroprocessing and/or hydrocracking process IFP Energies Nouvelles (FR) 2026-05-19 US claimed
CN-119285941-B Low-sensitization aspartate resin compound and preparation process thereof 深圳飞扬骏研新材料股份有限公司 2026-05-19 CN claimed
CN-122070479-A Ultrasonic indicating device and method for monitoring ultrasonic treatment JP实验室股份有限公司 2026-05-19 CN claimed
CN-121628009-B Polycarboxylic acid additive for enhancing low-activity admixture and preparation method thereof 北京厚德交通科技股份有限公司 2026-05-19 CN claimed
CN-122036552-A Method for separating acetonitrile from acetonitrile-containing wastewater 华东理工大学 2026-05-15 CN claimed
CN-122036783-A Organosilicon modified polyaspartic acid ester polyurea and preparation method thereof 深圳市宝安区新材料研究院 2026-05-15 CN claimed
EP-4558588-B1 HYDROTREATMENT PROCESS USING A SEQUENCE OF CATALYSTS WITH A CATALYST BASED ON NICKEL AND TUNGSTEN ON A SILICA-ALUMINA SUPPORT IFP ENERGIES NOW (FR) 2026-05-13 EP claimed
US-4000958-A Method for treating leather SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-01-04 US claimed
US-3994841-A DICARBOXY SULFIDE COMPOUND SEKISUI KASEIHIN KOGYO KABUSHIKI KAISHA (JA) 1976-11-30 US claimed
US-3991226-A Method of creating an image using hybrid liquid toners PHILIP A. HUNT CHEMICAL CORPORATION (US) 1976-11-09 US claimed
US-3990980-A Hybrid liquid toners PHILIP A. HUNT CHEMICAL CORPORATION (US) 1976-11-09 US claimed
US-3990459-A Cationic graft and cross-linked copolymers in wavesetting lotions SOCIETE ANONYME DITE: L'OREAL (FR) 1976-11-09 US claimed
US-3969433-A ADDITION POLYMER KOSE AKIRA 1976-07-13 US claimed
US-3957732-A ALTERNATING COPOLYMERS HAVING FUNCTIONAL GROUP AND PROCESS FOR PRODUCING SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1976-05-18 US claimed
US-3952023-A Method for preparing adduct of butadiene polymer or copolymer and α, β-ethylenically unsaturated dicarboxylic acid compound NIPPON OIL COMPANY LTD. (JA) 1976-04-20 US claimed
US-3946749-A HAIR COSMETIC COMPOSITIONS BASED ON GRAFTED AND CROSSLINKED COPOLYMERS L'OREAL (FR) 1976-03-30 US claimed
US-3941912-A Copolymer latex and paper coating composition thereof SUMITOMO NAUGATUCK CO., LTD. (JA) 1976-03-02 US claimed