Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12844412 | 0.83 | CYP2D6 (0.53) | CHRNB2CHRNA4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14331100 | 0.83 | KDM4E (0.55) | CHRNB2CHRNA4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12866793 | 0.82 | GGPS1 (0.50) | KDM4EALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL108446 | 0.81 | KEAP1 (0.58) | CHRNB2CHRNA4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2422195 | 0.81 | KDM4E (0.57) | CHRNB2CHRNA4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL3636625 | 0.81 | KDM4E (0.57) | CHRNB2CHRNA4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL679020 | 0.81 | HRH3 (0.67) | KDM4EALDH1A1SMN1; SMN2HRH3CYP3A4 | |
| SCHEMBL10224056 | 0.81 | GGPS1 (0.46) | LMNAGGPS1 | |
| Hydrochloric Acid SCHEMBL16497261 | 0.80 | KDM4E (0.56) | CHRNB2CHRNA4KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11254964 | 0.80 | KDM4E (0.59) | KDM4EALDH1A1SMN1; SMN2HRH3ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902373-B2 | asthma; for treating prostaglandin D2 mediated diseases; e.g. 6-(3-fluorophenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]nicotinamide | PFIZER INC (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080146569-A1 | Nicotinamide Derivatives | PFIZER INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146569-A1 | Nicotinamide Derivatives | NNT, NAMPT, NADK | CHRNB2 800/4885CHRNA4 530/4885KDM4E 3026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.