Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 8/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.49 |
| ▸ | TEK | Q02763 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 2/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13459592 | 0.79 | RIPK1 (0.69) | RIPK1KDRTRPV1BLMPDGFRB | |
| SCHEMBL1880281 | 0.76 | MAP2 (0.53) | RIPK1KDRBLMPDGFRBFLT3 | |
| SCHEMBL118026 | 0.74 | KDR (1.00) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL29364392 | 0.74 | KDR (1.00) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL9190713 | 0.74 | KDR (0.72) | KDRTRPV1BLMBRAFCA1 | |
| SCHEMBL3235295 | 0.74 | KDR (0.64) | RIPK1KDRTRPV1BLMPDGFRB | |
| SCHEMBL12776282 | 0.73 | RIPK1 (0.49) | RIPK1KDRBLMPDGFRBFLT3 | |
| SCHEMBL23195078 | 0.73 | KDR (0.44) | KDRTRPV1BRAF | |
| SCHEMBL3847163 | 0.72 | BRAF (0.57) | RIPK1KDRPDGFRBFLT3BRAF | |
| SCHEMBL4477773 | 0.72 | KDR (0.55) | RIPK1KDRTRPV1PDGFRBFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011038579-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | ZHEJIANG BETA PHARMA INC. (CN) | 2011-04-07 | — | — | WO | disclosed |