Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15767035 | 0.79 | GRM5 (0.44) | PARP1SMN1; SMN2TP53 | |
| SCHEMBL19497542 | 0.77 | MCHR1 (0.44) | PARP1USP7CA2TRPA1KDM4E | |
| SCHEMBL25045598 | 0.76 | SMN1; SMN2 (0.36) | KDM4EALDH1A1SMN1; SMN2HPGDNPC1 | |
| SCHEMBL1905278 | 0.76 | KDM4E (0.38) | PARP1USP7CA2TRPA1KDM4E | |
| SCHEMBL31035573 | 0.76 | PARP1 (0.36) | PARP1USP7CA2TRPA1KDM4E | |
| SCHEMBL25670702 | 0.76 | KDM4E (0.41) | PARP1USP7CA2KDM4EALDH1A1 | |
| SCHEMBL23530832 | 0.76 | NOTUM (0.43) | PARP1USP7CA2KDM4EALDH1A1 | |
| SCHEMBL4889270 | 0.76 | PARP1 (0.39) | PARP1USP7CA2TRPA1KDM4E | |
| SCHEMBL12778283 | 0.75 | KDM4E (0.54) | USP7TRPA1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL28535736 | 0.74 | TLR9 (0.57) | PARP1KDM4EALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011050160-A1 | PHARMACEUTICALS, COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2011-04-28 | — | — | WO | disclosed |