Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 8/20 | 0.53 |
| ▸ | INSR | P06213 | 5/20 | 0.53 |
| ▸ | IGF1R | P08069 | 5/20 | 0.53 |
| ▸ | ZAP70 | P43403 | 7/20 | 0.53 |
| ▸ | ULK1 | O75385 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14191671 | 1.00 | ALK (0.53) | ALKINSRIGF1RZAP70ULK1 | |
| SCHEMBL12918013 | 0.93 | ZAP70 (0.61) | ALKINSRIGF1RZAP70ULK1 | |
| SCHEMBL12780272 | 0.93 | ZAP70 (0.61) | ALKINSRIGF1RZAP70ULK1 | |
| SCHEMBL12780539 | 0.92 | ZAP70 (0.61) | ALKINSRIGF1RZAP70ULK1 | |
| SCHEMBL12780279 | 0.92 | ZAP70 (0.61) | ALKINSRIGF1RZAP70ULK1 | |
| SCHEMBL12781754 | 0.92 | ALK (0.51) | ALKINSRIGF1RZAP70ULK1 | |
| SCHEMBL12780327 | 0.92 | ZAP70 (0.53) | ALKINSRIGF1RZAP70ULK1 | |
| SCHEMBL12780160 | 0.92 | ALK (0.51) | ALKINSRIGF1RZAP70ULK1 | |
| SCHEMBL12780329 | 0.92 | ZAP70 (0.53) | ALKINSRIGF1RZAP70ULK1 | |
| SCHEMBL1912061 | 0.91 | ALK (0.64) | ALKINSRIGF1RZAP70MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098280-A1 | 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2011-04-28 | — | — | US | disclosed |
| US-20080132504-A1 | 2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098280-A1 | 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | TYMS, TYMP, DPYD | ALK 3384/4885INSR 3201/4885IGF1R 4627/4885 |
| US-20080132504-A1 | 2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders | TYMS, TYMP, DPYD | ALK 3200/4885INSR 2899/4885IGF1R 4633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.