Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 8/20 | 0.61 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.51 |
| ▸ | INSR | P06213 | 5/20 | 0.51 |
| ▸ | IGF1R | P08069 | 4/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 3/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12780539 | 1.00 | ZAP70 (0.61) | ZAP70ALKINSRIGF1RPTK2 | |
| SCHEMBL12780329 | 0.94 | ZAP70 (0.53) | ZAP70ALKINSRIGF1RPTK2 | |
| SCHEMBL12780327 | 0.94 | ZAP70 (0.53) | ZAP70ALKINSRIGF1RPTK2 | |
| SCHEMBL14191671 | 0.92 | ALK (0.53) | ZAP70ALKINSRIGF1RPTK2 | |
| SCHEMBL12780153 | 0.92 | ALK (0.53) | ZAP70ALKINSRIGF1RPTK2 | |
| SCHEMBL1912067 | 0.92 | ZAP70 (0.72) | ZAP70ALKINSRIGF1RPTK2 | |
| SCHEMBL10208704 | 0.92 | ZAP70 (0.72) | ZAP70ALKINSRIGF1RPTK2 | |
| SCHEMBL12892739 | 0.92 | ZAP70 (0.72) | ZAP70ALKINSRIGF1RPTK2 | |
| SCHEMBL12918034 | 0.92 | ALK (0.55) | ZAP70ALKINSRIGF1RPTK2 | |
| SCHEMBL12917676 | 0.92 | ALK (0.55) | ZAP70ALKINSRIGF1RPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098280-A1 | 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2011-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098280-A1 | 2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | TYMS, TYMP, DPYD | ZAP70 341/4885ALK 3384/4885INSR 3201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.