Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 1/20 | 0.36 |
| ▸ | PYGM | P11217 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.32 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.32 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.31 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.31 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.31 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1278044 | 1.00 | HRH4 (0.36) | HRH4PYGLPYGMVCPGABRA1 | |
| SCHEMBL1277701 | 0.85 | GABRA1 (0.32) | VCPGABRA1GABRR1GABRA5GABRB2 | |
| SCHEMBL1277705 | 0.85 | GABRA1 (0.32) | VCPGABRA1GABRR1GABRA5GABRB2 | |
| SCHEMBL1277961 | 0.85 | GABRA1 (0.32) | GABRA1GABRR1GABRA5GABRB2GABRA4 | |
| SCHEMBL1277963 | 0.85 | GABRA1 (0.32) | GABRA1GABRR1GABRA5GABRB2GABRA4 | |
| SCHEMBL1278346 | 0.84 | GABRA1 (0.34) | GABRA1GABRR1GABRA5GABRB2GABRA4 | |
| SCHEMBL1278149 | 0.84 | GABRA1 (0.32) | GABRA1GABRR1GABRA5GABRB2GABRA4 | |
| SCHEMBL1278189 | 0.84 | HRH4 (0.38) | HRH4GABRA1GABRR1GABRA5GABRB2 | |
| SCHEMBL1278349 | 0.84 | GABRA1 (0.34) | GABRA1GABRR1GABRA5GABRB2GABRA4 | |
| SCHEMBL1278145 | 0.84 | GABRA1 (0.32) | GABRA1GABRR1GABRA5GABRB2GABRA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309586-B2 | Glucokinase activators and pharmaceutical compositions containing the same as an active ingredient | LG LIFE SCIENCES LTD. (KR) | 2012-11-13 | — | — | US | disclosed |
| US-20120088760-A1 | GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT | LG CHEM, LTD. (KR) | 2012-04-12 | — | — | US | disclosed |
| US-20100267708-A1 | GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT | LG LIFE SCIENCES LTD. (KR) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088760-A1 | GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT | GCKR, GCK, GALK1 | HRH4 4816/4885PYGL 32/4885PYGM 45/4885 |
| US-20100267708-A1 | GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT | GCK, GCKR, HK1 | HRH4 4799/4885PYGL 49/4885PYGM 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.