Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12784569 | 0.93 | ADRB3 (0.32) | ADRB3ADRA2BADRA2C | |
| SCHEMBL12808491 | 0.93 | F2 (0.34) | F2F10PRSS1PDE4B | |
| SCHEMBL12808437 | 0.93 | ADRB3 (0.38) | F2F10PRSS1ADRB3ADRA2B | |
| SCHEMBL8237405 | 0.93 | F2 (0.39) | F2F10PRSS1ADRB3ADRA2B | |
| SCHEMBL13711316 | 0.89 | ADRB3 (0.33) | F2F10PRSS1ADRB3ADRA2B | |
| SCHEMBL12785105 | 0.89 | F2 (0.37) | F2F10PRSS1ADRB3ADRA2B | |
| SCHEMBL13711314 | 0.87 | CTSB (0.38) | F2F10PRSS1ADRB3ADRA2B | |
| SCHEMBL12808087 | 0.86 | CYP3A4 (0.32) | ADRB3ADRA2BADRA2C | |
| SCHEMBL12784601 | 0.85 | ADRB3 (0.34) | F2F10PRSS1ADRB3ADRA2B | |
| SCHEMBL8378473 | 0.85 | ADRB3 (0.42) | F2F10PRSS1ADRB3ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305695-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2305697-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2305698-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-2103623-A2 | Novel macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2009-09-23 | — | — | EP | disclosed |