Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMO | Q99835 | 3/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12786175 | 0.88 | MEN1 (0.60) | KMT2AMEN1GFERALDH1A1ABCG2 | |
| SCHEMBL12786172 | 0.85 | KMT2A (0.70) | KMT2AMEN1GFERHPGDALDH1A1 | |
| SCHEMBL12786177 | 0.80 | MEN1 (0.57) | KMT2AMEN1GFERHPGDALDH1A1 | |
| SCHEMBL1396118 | 0.79 | KMT2A (0.70) | KMT2AMEN1GFERHPGDALDH1A1 | |
| SCHEMBL2210096 | 0.78 | MEN1 (1.00) | KMT2AMEN1GFERHPGDALDH1A1 | |
| SCHEMBL12786176 | 0.77 | MEN1 (0.55) | KMT2AMEN1GFERALDH1A1TSHR | |
| SCHEMBL27829670 | 0.77 | KMT2A (0.72) | KMT2AMEN1GFERHPGDALDH1A1 | |
| SCHEMBL7487101 | 0.76 | MEN1 (0.70) | KMT2AMEN1GFERHPGDALDH1A1 | |
| SCHEMBL23064355 | 0.75 | HTR2A (0.48) | DRD2DRD4 | |
| SCHEMBL13181182 | 0.73 | KMT2A (0.66) | KMT2AMEN1GFERHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771175-B1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-23 | — | — | EP | disclosed |
| US-20150072972-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-12 | — | — | US | disclosed |
| US-20150072972-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-03-12 | — | — | US | disclosed |
| US-8946221-B2 | Phthalazine derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2015-02-03 | — | — | US | disclosed |
| US-8946221-B2 | Phthalazine derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA, NV (BE) | 2015-02-03 | — | — | US | disclosed |
| US-20110065684-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | MEVELLEC LAURENCE ANNE | 2011-03-17 | — | — | US | disclosed |
| US-7803795-B2 | Phthalazine derivatives as parp inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-28 | — | — | US | disclosed |
| US-20080139568-A1 | Phthalazine Derivatives as Parp Inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150072972-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP11 | KMT2A 129/4885MEN1 1665/4885GFER 3961/4885 |
| US-20080139568-A1 | Phthalazine Derivatives as Parp Inhibitors | PARP1, PARP2, PARP11 | KMT2A 131/4885MEN1 1695/4885GFER 3959/4885 |
| US-20110065684-A1 | PHTHALAZINE DERIVATIVES AS PARP INHIBITORS | PARP1, PARP2, PARP11 | KMT2A 129/4885MEN1 1665/4885GFER 3961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.