Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1279219 | 1.00 | SLC6A4 (0.45) | SLC6A4SLC6A2TP53THRBMMP2 | |
| SCHEMBL1279417 | 0.85 | SLC6A4 (0.51) | SLC6A4SLC6A2HTR2CMBTPS1EPHX2 | |
| SCHEMBL1279653 | 0.85 | SLC6A4 (0.51) | SLC6A4SLC6A2MMP2MMP3MMP9 | |
| SCHEMBL1279650 | 0.85 | SLC6A4 (0.51) | SLC6A4SLC6A2MMP2MMP3MMP9 | |
| SCHEMBL1279442 | 0.84 | SLC6A4 (0.54) | SLC6A4SLC6A2HTR2CMBTPS1 | |
| SCHEMBL1279438 | 0.84 | SLC6A4 (0.54) | SLC6A4SLC6A2HTR2CMBTPS1 | |
| SCHEMBL1279518 | 0.84 | SLC6A4 (0.47) | SLC6A4SLC6A2MMP2MMP3MMP9 | |
| SCHEMBL1278998 | 0.81 | SLC6A2 (0.55) | SLC6A4SLC6A2HTR2C | |
| SCHEMBL14813689 | 0.81 | SLC6A2 (0.55) | SLC6A4SLC6A2HTR2C | |
| SCHEMBL1279877 | 0.81 | SLC6A2 (0.55) | SLC6A4SLC6A2HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000191-B2 | Serotonin reuptake inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-04-07 | — | — | US | disclosed |
| EP-2627630-B1 | SEROTONIN REUPTAKE INHIBITORS | THERAVANCE BIOPHARMA R & D IP LLC (US) | 2014-12-31 | — | — | EP | disclosed |
| US-20140243536-A1 | SEROTONIN REUPTAKE INHIBITORS | THERAVANCE, INC. (US) | 2014-08-28 | — | — | US | disclosed |
| US-8729119-B2 | Serotonin reuptake inhibitors | THERAVANCE, INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-20130253013-A1 | SEROTONIN REUPTAKE INHIBITORS | THERAVANCE, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-8471040-B2 | Serotonin reuptake inhibitors | THERAVANCE, INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20120088799-A1 | SEROTONIN REUPTAKE INHIBITORS | THERAVANCE, INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130253013-A1 | SEROTONIN REUPTAKE INHIBITORS | SLC6A4, SLC6A2, TPH1 | SLC6A4 1/4885SLC6A2 2/4885TP53 4803/4885 |
| US-20120088799-A1 | SEROTONIN REUPTAKE INHIBITORS | SLC6A4, SLC6A2, TPH1 | SLC6A4 1/4885SLC6A2 2/4885TP53 4803/4885 |
| US-20140243536-A1 | SEROTONIN REUPTAKE INHIBITORS | SLC6A4, SLC6A2, TPH1 | SLC6A4 1/4885SLC6A2 2/4885TP53 4803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.