Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | STAT6 | P42226 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.33 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662480 | 0.85 | NPBWR1 (0.37) | IGF1RULK1JAK3GUCY1B2GUCY1A2 | |
| SCHEMBL12797021 | 0.81 | ADORA2A (0.40) | ADORA2AADORA1ADORA3ADORA2BSTAT6 | |
| SCHEMBL12797295 | 0.80 | FLT4 (0.41) | ADORA2AADORA1IGF1RJAK3PTK2 | |
| SCHEMBL12797025 | 0.78 | IGF1R (0.42) | ADORA2AADORA1IGF1RJAK3CCNE1 | |
| SCHEMBL12797024 | 0.78 | IGF1R (0.42) | ADORA2AADORA1IGF1RJAK3CCNE1 | |
| SCHEMBL12796992 | 0.77 | JAK3 (0.47) | JAK3CDK2 | |
| SCHEMBL12796158 | 0.77 | FLT4 (0.40) | ADORA2AADORA1STAT6JAK3PIK3CD | |
| SCHEMBL12795250 | 0.76 | MAPK1 (0.44) | ADORA2AADORA1JAK3CDK2PTK2 | |
| SCHEMBL12796169 | 0.75 | EIF2AK4 (0.52) | JAK3 | |
| SCHEMBL12797296 | 0.74 | JAK3 (0.47) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |