Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 8/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15397182 | 0.93 | CXCR4 (0.36) | HDAC3HDAC1HDAC2HDAC6CXCR4 | |
| SCHEMBL10145784 | 0.88 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6CXCR4 | |
| SCHEMBL12796272 | 0.88 | MAPK8 (0.45) | HDAC3HDAC1HDAC2HDAC6CXCR4 | |
| SCHEMBL541449 | 0.88 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6CXCR4 | |
| SCHEMBL541330 | 0.88 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6CXCR4 | |
| SCHEMBL6521503 | 0.87 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6CXCR4 | |
| SCHEMBL541695 | 0.87 | VNN1 (0.45) | HDAC3HDAC1HDAC2HDAC6CXCR4 | |
| SCHEMBL6521507 | 0.87 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6CXCR4 | |
| SCHEMBL541715 | 0.86 | HDAC3 (0.40) | HDAC3HDAC1HDAC2HDAC6CXCR4 | |
| SCHEMBL541776 | 0.85 | GAA (0.41) | HDAC3HDAC1HDAC2HDAC6CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524727-B2 | Pyrimidine compound | ASTELLAS PHARMA INC. (JP) | 2013-09-03 | — | — | US | disclosed |
| US-20110053912-A1 | PYRIMIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-03-03 | — | — | US | disclosed |
| WO-2010113834-A1 | PYRIMIDINE COMPOUND | アステラス製薬株式会社 (JP) | 2010-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053912-A1 | PYRIMIDINE COMPOUND | CNR2, CNR1, P2RY2 | HDAC3 2151/4885HDAC1 3139/4885HDAC2 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.