Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ACSS2 | Q9NR19 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18708430 | 0.89 | KMT2A (0.44) | KMT2AACSS2MGLLNR1I2EGFR | |
| SCHEMBL21017338 | 0.89 | KMT2A (0.48) | KMT2AACSS2MGLLNR1I2EGFR | |
| SCHEMBL10238003 | 0.83 | KMT2A (0.52) | KMT2AACSS2MGLLADRA2AADORA3 | |
| SCHEMBL10239606 | 0.82 | KMT2A (0.51) | KMT2AMGLLHSD17B10KDM4EMEN1 | |
| SCHEMBL13057629 | 0.81 | KMT2A (0.49) | KMT2AMGLLKDM4ELMNATSHR | |
| SCHEMBL13358852 | 0.81 | KMT2A (0.50) | KMT2AACSS2MGLLHSD17B10KDM4E | |
| SCHEMBL10238004 | 0.80 | KMT2A (0.52) | KMT2AACSS2MGLLLMNAPARP1 | |
| SCHEMBL13599977 | 0.79 | LMNA (0.53) | KMT2AHSD17B10KDM4ELMNATSHR | |
| SCHEMBL13058152 | 0.79 | KMT2A (0.66) | KMT2AMGLLLMNATSHRPARP1 | |
| SCHEMBL2024958 | 0.79 | KMT2A (0.66) | KMT2AMGLLKDM4ELMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2939674-A1 | COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE | PTC Therapeutics, Inc. (US) | 2015-11-04 | — | — | EP | disclosed |
| EP-2311455-B1 | Compounds for nonsense suppression, and methods for their use | PTC THERAPEUTICS INC (US) | 2015-07-15 | — | — | EP | disclosed |
| EP-2311455-A1 | Compounds for nonsense suppression, and methods for their use | PTC Therapeutics, Inc. (US) | 2011-04-20 | — | — | EP | disclosed |
| EP-2301538-A1 | Compounds for nonsense suppression, and methods for their use | PTC Therapeutics, Inc. (US) | 2011-03-30 | — | — | EP | disclosed |
| EP-2301536-A1 | Pyrazole or triazole compounds and their use for the manufacture of a medicament for treating somatic mutation-related diseases | PTC Therapeutics, Inc. (US) | 2011-03-30 | — | — | EP | disclosed |