Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12796990 | 0.89 | LRRK2 (0.36) | JAK3MAP4K1LRRK2MAP3K14ADORA2A | |
| SCHEMBL12797294 | 0.89 | JAK3 (0.39) | JAK3JAK2JAK1 | |
| SCHEMBL12796218 | 0.88 | LRRK2 (0.36) | JAK3MAP4K1LRRK2TTKEIF2AK4 | |
| SCHEMBL12796184 | 0.88 | JAK3 (0.39) | JAK3MAP4K1LRRK2EIF2AK4MAP4K3 | |
| SCHEMBL12795371 | 0.88 | JAK3 (0.40) | JAK3LRRK2TTKEIF2AK4 | |
| SCHEMBL1663154 | 0.88 | MAP3K14 (0.40) | JAK3LRRK2TTKMAP3K14JAK2 | |
| SCHEMBL12797397 | 0.85 | TTK (0.38) | JAK3LRRK2TTKMAP3K14PIK3CD | |
| SCHEMBL12959677 | 0.82 | NPBWR1 (0.38) | JAK3LRRK2MAP3K14JAK2JAK1 | |
| SCHEMBL12959686 | 0.81 | TTK (0.35) | JAK3LRRK2TTKMAP3K14PIK3CD | |
| SCHEMBL12797396 | 0.81 | MAP3K14 (0.40) | JAK3LRRK2TTKMAP3K14PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011048082-A1 | HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS | CELLZOME LIMITED (GB) | 2011-04-28 | — | — | WO | disclosed |