⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14770233 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL6774435 | 0.98 | ACE (0.46) | — | |
| SCHEMBL12674159 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL9342155 | 0.79 | ACE (0.35) | — | |
| SCHEMBL28727117 | 0.77 | ACE (0.58) | — | |
| SCHEMBL2229670 | 0.74 | ACE (0.59) | — | |
| SCHEMBL14097930 | 0.74 | — | — | |
| SCHEMBL4454388 | 0.74 | ACE (0.59) | — | |
| SCHEMBL4461003 | 0.74 | ACE (0.59) | — | |
| SCHEMBL14572721 | 0.74 | ACE (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| US-7897765-B2 | Therapeutic compounds and uses thereof | ELIXIR PHARMACEUTICALS, INC. (US) | 2011-03-01 | — | — | US | disclosed |
| US-20100267719-A1 | Enhanced Indolinone Based Protein Kinase Inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-10-21 | — | — | US | disclosed |
| US-20090305382-A1 | ALKOXY INDOLINONE BASED PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-10 | — | — | US | disclosed |
| US-7629339-B2 | inhibitors of protein kinases and are useful in treating cancer; 4-({5-[5-Fluoro-2-oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carbonyl}-amino)-3-methoxy-butyric acid; anticarcinogenic agent | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-12-08 | — | — | US | disclosed |
| US-20090264410-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | ELIXIR PHARMACEUTICALS, INC. (US) | 2009-10-22 | — | — | US | disclosed |
| US-7504506-B2 | Therapeutic compounds and uses thereof | ELIXIR PHARMACEUTICALS, INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20080044881-A1 | Advanced Indolinone Based Protein Kinase Inhibitors | SCRIPPS RESEARCH INSTITUTE, THE | 2008-02-21 | — | — | US | disclosed |
| US-20070072934-A1 | Alkoxy indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-03-29 | — | — | US | disclosed |
| US-20070072934-A1 | Alkoxy indolinone based protein kinase inhibitors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-03-29 | — | — | US | disclosed |