Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4454388 | 1.00 | ACE (0.59) | ACEPOLBAPEX1TDP1EGLN1 | |
| SCHEMBL4461003 | 1.00 | ACE (0.59) | ACEPOLBAPEX1TDP1EGLN1 | |
| SCHEMBL247111 | 0.84 | ACE (0.58) | ACEPOLBAPEX1TDP1EGLN1 | |
| SCHEMBL28727117 | 0.84 | ACE (0.58) | ACEPOLBAPEX1TDP1EGLN1 | |
| SCHEMBL1075993 | 0.83 | ACE (0.43) | ACEPIN1 | |
| SCHEMBL28290379 | 0.78 | ACE (0.43) | ACEPOLBAPEX1TDP1 | |
| SCHEMBL6792635 | 0.78 | ACE (0.75) | ACE | |
| SCHEMBL6792627 | 0.78 | ACE (0.75) | ACE | |
| SCHEMBL4885276 | 0.78 | ACE (0.51) | ACEITGB2ICAM1ITGAL | |
| SCHEMBL5127864 | 0.78 | ACE (0.51) | ACEITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025919-A1 | AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20230416199-A1 | INHIBITORS OF AMINO ACID TRANSPORT | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-12-28 | — | — | US | disclosed |
| WO-2023225302-A1 | AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2023-11-23 | — | — | WO | disclosed |
| WO-2023169573-A1 | POLθ INHIBITOR | 武汉人福创新药物研发中心有限公司 | 2023-09-14 | — | — | WO | disclosed |
| EP-3959208-B1 | CYCLEN BASED COMPOUNDS, COORDINATION COMPOUNDS, PEPTIDES, PHARMACEUTICAL PREPARATION, AND USE THEREOF | USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR V V I (CZ) | 2023-07-05 | — | — | EP | disclosed |
| US-20220218849-A1 | CYCLEN BASED COMPOUNDS, COORDINATION COMPOUNDS, PEPTIDES, PHARMACEUTICAL PREPARATION, AND USE THEREOF | Ustav Organicke Chemie A Biochemie AV CR v.v.i. (CZ) | 2022-07-14 | — | — | US | disclosed |
| CN-114456101-A | Synthesis method of key intermediate for synthesizing PF-07321332 | 上海璨谊生物科技有限公司 | 2022-05-10 | — | — | CN | disclosed |
| WO-2022087630-A1 | INHIBITORS OF AMINO ACID TRANSPORT | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
| EP-3757098-A1 | CYCLEN BASED COMPOUNDS, COORDINATION COMPOUNDS, PEPTIDES, PHARMACEUTICAL PREPARATION, AND USE THEREOF | Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) | 2020-12-30 | — | — | EP | disclosed |
| EP-2970278-A1 | PYRROLO[2,3-B]PYRIDINE CDK9 KINASE INHIBITORS | AbbVie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014139328-A1 | PYRROLO[2,3-B]PYRIDINE CDK9 KINASE INHIBITORS | ABBVIE INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| EP-2747569-A1 | COMBINATION TREATMENTS FOR HEPATITIS C | GlaxoSmithKline LLC (US) | 2014-07-02 | — | — | EP | disclosed |
| WO-2013028953-A1 | COMBINATION TREATMENTS FOR HEPATITIS C | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |
| WO-2011091407-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE LLP (US) | 2011-07-28 | — | — | WO | disclosed |
| US-20090042854-A1 | Hexahydro-3H-Pyrrolizin-3-Ones Useful as Tachykinin Receptor Antagonists | MERCK SHARP & DOHME CORP. | 2009-02-12 | — | — | US | disclosed |
| EP-1978965-A2 | HEXAHYDRO-3H-PYRROLIZIN-3-ONES USEFUL AS TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007087224-A2 | HEXAHYDRO-3H-PYRROLIZIN-3-ONES USEFUL AS TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042854-A1 | Hexahydro-3H-Pyrrolizin-3-Ones Useful as Tachykinin Receptor Antagonists | TACR1, PROKR1, TACR2 | ACE 196/4885POLB 3324/4885APEX1 3021/4885 |
| US-20220218849-A1 | CYCLEN BASED COMPOUNDS, COORDINATION COMPOUNDS, PEPTIDES, PHARMACEUTICAL PREPARATION, AND USE THEREOF | CCNY, CCNC, CPN1 | ACE 2798/4885POLB 750/4885APEX1 2989/4885 |
| US-20240025919-A1 | AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF | AZI2, TET3, OXA1L | ACE 3516/4885POLB 1891/4885APEX1 4139/4885 |
| US-20230416199-A1 | INHIBITORS OF AMINO ACID TRANSPORT | SLC1A5, SLC7A1, SLC7A5 | ACE 1294/4885POLB 3896/4885APEX1 1870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.