Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14013167 | 0.93 | NPC1 (0.54) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL1663386 | 0.89 | MEN1 (0.51) | NPC1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14176439 | 0.84 | SMN1; SMN2 (0.50) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL10426957 | 0.84 | MEN1 (0.51) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL14176438 | 0.82 | SMN1; SMN2 (0.51) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL14176441 | 0.79 | MAPT (0.55) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL31710349 | 0.78 | MEN1 (0.60) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL14176435 | 0.77 | MAPT (0.56) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL11303092 | 0.77 | CYP3A4 (0.60) | NPC1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL13936249 | 0.77 | KLKB1 (0.56) | NPC1MEN1KMT2ASMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305652-A2 | Trisubstituted quinazolinone derivatives as vanilloid antagonists | Novartis AG (CH) | 2011-04-06 | — | — | EP | disclosed |