Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.54 |
| ▸ | BCR | P11274 | 7/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | PRKCA | P17252 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.48 |
| ▸ | ABL2 | P42684 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801194 | 0.90 | AAK1 (0.47) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL12801096 | 0.89 | JAK2 (0.61) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL12522328 | 0.88 | AAK1 (0.57) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL12801324 | 0.83 | PDPK1 (0.59) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL12522222 | 0.83 | ABL1 (0.51) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL12801118 | 0.82 | CDK5 (0.73) | ABL1BCRPRKCAEGFRCDK5 | |
| SCHEMBL12801697 | 0.81 | ABL1 (0.50) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL12801601 | 0.81 | ABL1 (0.50) | ABL1BCRPDGFRBPDGFRAPRKCA | |
| SCHEMBL14253949 | 0.81 | PIK3CG (0.73) | ABL1BCREGFRCDK5JAK2 | |
| SCHEMBL14253944 | 0.81 | IKBKB (0.61) | ABL1PRKCAEGFRCDK5JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |