Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | PRKCA | P17252 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.46 |
| ▸ | PRKCG | P05129 | 2/20 | 0.46 |
| ▸ | PRKCB | P05771 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | PRKCH | P24723 | 2/20 | 0.46 |
| ▸ | PRKCI | P41743 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801296 | 0.87 | JAK2 (0.52) | IKBKBHDAC1JAK2JAK3CAMKK2 | |
| SCHEMBL12275484 | 0.86 | JAK2 (0.48) | IKBKBJAK2JAK3CAMKK2PIK3CG | |
| SCHEMBL12801541 | 0.85 | JAK2 (0.56) | IKBKBJAK2JAK3CAMKK2PIK3CG | |
| SCHEMBL12801101 | 0.83 | JAK2 (0.58) | IKBKBJAK2JAK3CAMKK2PIK3CG | |
| SCHEMBL12801645 | 0.83 | PIK3CG (0.55) | IKBKBHDAC1JAK2JAK3PIK3CG | |
| SCHEMBL12801096 | 0.83 | JAK2 (0.61) | IKBKBHDAC1JAK2JAK3PIK3CG | |
| SCHEMBL12800912 | 0.82 | JAK2 (0.53) | IKBKBJAK2JAK3PIK3CGPLK1 | |
| SCHEMBL12801115 | 0.81 | PIK3CG (0.57) | IKBKBJAK2PIK3CGPRKCAEGFR | |
| SCHEMBL12801280 | 0.80 | IKBKB (0.58) | IKBKBHDAC1JAK2JAK3CAMKK2 | |
| SCHEMBL12522350 | 0.80 | IKBKB (0.59) | IKBKBJAK2JAK3CAMKK2PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |