Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 6/20 | 0.55 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.55 |
| ▸ | JAK2 | O60674 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | PRKCG | P05129 | 2/20 | 0.48 |
| ▸ | PRKCB | P05771 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801541 | 0.91 | JAK2 (0.56) | PIK3CGPIK3CAPIK3CBJAK2CDK2 | |
| SCHEMBL12800912 | 0.88 | JAK2 (0.53) | PIK3CGPIK3CAPIK3CBJAK2CDK2 | |
| SCHEMBL12801115 | 0.87 | PIK3CG (0.57) | PIK3CGPIK3CAPIK3CBJAK2CDK2 | |
| SCHEMBL12801101 | 0.87 | JAK2 (0.58) | PIK3CGPIK3CAPIK3CBJAK2CDK2 | |
| SCHEMBL12801296 | 0.86 | JAK2 (0.52) | PIK3CGPIK3CAPIK3CBJAK2CDK2 | |
| SCHEMBL12801546 | 0.85 | PIK3CG (0.53) | PIK3CGPIK3CAPIK3CBJAK2CDK2 | |
| SCHEMBL12801558 | 0.85 | JAK2 (0.51) | PIK3CGPIK3CAPIK3CBJAK2CDK2 | |
| SCHEMBL12800916 | 0.85 | JAK2 (0.53) | PIK3CGPIK3CAPIK3CBJAK2CDK2 | |
| SCHEMBL12275325 | 0.84 | PIK3CA (0.52) | PIK3CGPIK3CAPIK3CBJAK2CDK2 | |
| SCHEMBL12801103 | 0.83 | IKBKB (0.53) | PIK3CGPIK3CAPIK3CBJAK2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |