Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 1.00 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.71 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.67 |
| ▸ | JAK3 | P52333 | 3/20 | 0.66 |
| ▸ | TYK2 | P29597 | 2/20 | 0.66 |
| ▸ | JAK1 | P23458 | 2/20 | 0.66 |
| ▸ | PLK1 | P53350 | 1/20 | 0.65 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12274649 | 0.87 | JAK2 (0.77) | JAK2MAPK8MAPK10CAMK2DPLK4 | |
| SCHEMBL12274500 | 0.87 | CAMK2D (0.81) | JAK2MAPK8MAPK10CAMK2DPLK4 | |
| SCHEMBL4383881 | 0.86 | JAK2 (0.78) | JAK2PLK4JAK3TYK2JAK1 | |
| SCHEMBL28254694 | 0.86 | JAK2 (1.00) | JAK2MAPK8MAPK10PLK4JAK3 | |
| SCHEMBL12801273 | 0.86 | JAK2 (0.78) | JAK2MAPK8MAPK10CAMK2DPLK4 | |
| SCHEMBL3622937 | 0.85 | JAK2 (0.80) | JAK2MAPK8MAPK10CAMK2DJAK3 | |
| SCHEMBL3758720 | 0.85 | MAPK8 (0.75) | JAK2MAPK8MAPK10CAMK2DJAK3 | |
| Hydrochloric Acid SCHEMBL4377167 | 0.85 | JAK2 (0.77) | JAK2PLK4JAK3TYK2JAK1 | |
| SCHEMBL12800906 | 0.85 | JAK2 (0.74) | JAK2MAPK8MAPK10CAMK2DPLK4 | |
| SCHEMBL3750610 | 0.84 | JAK2 (0.72) | JAK2MAPK8MAPK10CAMK2DJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |